ArticleJournal of nephrology
Nicaragua revisited: evidence of lower prevalence of chronic kidney disease in a high-altitude, coffee-growing village.
Article in Journal of nephrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Heterogeneity in diagnostic criteria for chronic kidney disease of undetermined etiology (CKDu): a systematic review of the literature.BMC nephrology · 2025Pooled it
- Pesticide exposures and chronic kidney disease of unknown etiology: an epidemiologic review.Environmental health : a global access science source · 2017Pooled it
- CKD of Uncertain Etiology: A Systematic Review.Clinical journal of the American Society of Nephrology : CJASN · 2016Pooled it
- Article
- Creatinine standardization: a key consideration in evaluating whole blood creatinine monitoring systems for CKD screening.Analytical and bioanalytical chemistry · 2022Article
- Where do you live and what do you do? Two questions that might impact your kidney health.Frontiers in nephrology · 2022Review
- Environmental risk factors for reduced kidney function due to undetermined cause in India: an environmental epidemiologic analysis.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Climate Trends at a Hotspot of Chronic Kidney Disease of Unknown Causes in Nicaragua, 1973-2014.International journal of environmental research and public health · 2021Article
- Prevalence and Risk Factors for CKD in the General Population of Southwestern Nicaragua.Journal of the American Society of Nephrology : JASN · 2020Article
- Chronic kidney disease of non-traditional origin in Mesoamerica: a disease primarily driven by occupational heat stress.Revista panamericana de salud publica = Pan American journal of public health · 2020Article
- Risk factors for chronic kidney disease of non-traditional causes: a systematic review.Revista panamericana de salud publica = Pan American journal of public health · 2019Review
- What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis.Clinical kidney journal · 2018Article
- Genetic and environmental risk factors for chronic kidney disease.Kidney international supplements · 2017Review
- Rationale, description and baseline findings of a community-based prospective cohort study of kidney function amongst the young rural population of Northwest Nicaragua.BMC nephrology · 2017Article
- Quest to identify geochemical risk factors associated with chronic kidney disease of unknown etiology (CKDu) in an endemic region of Sri Lanka-a multimedia laboratory analysis of biological, food, and environmental samples.Environmental monitoring and assessment · 2016Article
- The Rivas Cohort Study: design and baseline characteristics of a Nicaraguan cohort.BMC nephrology · 2016Article
- Urine biomarkers of kidney injury among adolescents in Nicaragua, a region affected by an epidemic of chronic kidney disease of unknown aetiology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
- CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Review
- Chronic kidney disease in Nicaragua: a qualitative analysis of semi-structured interviews with physicians and pharmacists.BMC public health · 2013Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundChronic kidney disease (CKD) is found at epidemic levels in certain populations of the Pacific Coast in northwestern Nicaragua especially in younger men. There are knowledge gaps concerning CKD's prevalence in regions at higher altitudes.
methodsA cross-sectional study of adults between the ages of 20 and 60 years in 1 coffee-growing village in Nicaragua located at 1,000 m above sea level (MASL) altitude was performed. Predictors included participant sex, age, occupation, conventional CKD risk factors and other factors associated with CKD suggested by previous surveys in Central America. Outcomes included serum creatinine (SCr) values >1.2 mg/dL for men and >0.9 mg/dL for women, estimated glomerular filtration rate (GFR) <60 ml/min per 1.73 m2, dipstick proteinuria stratified as microalbuminuria (30-300 mg/dL) and macroalbuminuria (>300 mg/dL), hypertension and body mass index.
resultsOf 324 eligible participants, 293 were interviewed (90.4%), and 267 of those received the physical exam (82.4% overall). Of the sample, 45% were men. Prevalence rate of estimated GFR <60 ml/min per 1.73 m2 was 0 for men (0%) and 2 for women (1.4%). The prevalence of at least microalbuminuria was significantly higher among men compared with women (27.5% vs. 21.4%, respectively; p=0.02).
conclusionsThe CKD prevalence in this village is comparable to a previously studied Nicaraguan coffee-farming region and much lower than previously screened portions of northwestern Nicaragua. There is heterogeneity in CKD prevalence across Nicaragua. At this time, screenings should target individuals living in previously identified, higher risk regions. More work is needed to understand determinants of CKD in this resource-poor nation.
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