ArticleMolecular biology reports2012
The ribosomal protein L19 mRNA is induced by copper exposure in the swordtail fish, Xiphophorus helleri.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 12 citations in OpenAlex.
- Comparative transcriptome analysis of Labeo calbasu (Hamilton, 1822) from polluted and non-polluted rivers in India.PloS one · 2025Article
- High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines.Apoptosis : an international journal on programmed cell death · 2021Article
- Transcriptome Analysis of the Hepatopancreas in the Litopenaeus vannamei Responding to the Lead Stress.Biological trace element research · 2021Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Teleosts are useful vertebrate model species for understanding copper toxicity due to the dual entry route for copper intake via the gills and intestine. In this present study, we utilized the differential display reverse transcription-polymerase chain reaction to isolate potential novel hepatic genes induced by sublethal copper exposure in the freshwater swordtail fish, Xiphophorus helleri. Full length cloning of a cDNA fragment induced by copper exposure to 1 μg/ml during 24 h resulted in the positive identification of a hepatic ribosomal protein L19 (RPL19) gene. Further characterization of this gene revealed that its transcriptional expression was dependent on dosage and time of copper exposure. This study describes for the first time the involvement of RPL19 in copper toxicity, probably as a result of increase in ribosome synthesis rate to support activities such as cellular protein translation, transcriptional activation and mRNA stabilization during sublethal copper exposure.
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