SynthesisNeurology2011
Presence of baseline prehypertension and risk of incident stroke: a meta-analysis.
Synthesis in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Exercise Prescription in Individuals with Prehypertension and Hypertension: Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2024Pooled it
- 2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.Journal of the American College of Cardiology · 2019Guideline
- 2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.Circulation. Cardiovascular quality and outcomes · 2019Guideline
- Association between pre-hypertension and cardiovascular outcomes: a systematic review and meta-analysis of prospective studies.Current hypertension reports · 2013Pooled it
- Prehypertension and incidence of cardiovascular disease: a meta-analysis.BMC medicine · 2013Pooled it
- Effect of pre-diabetes on future risk of stroke: meta-analysis.BMJ (Clinical research ed.) · 2012Pooled it
- Hypertension in a Randomized Trial of Dolutegravir- Versus Efavirenz-Based Antiretroviral Therapy in Pregnant and Postpartum Women with HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Trial
- Study on the effect of community intervention on patients with hypertension in high-normal blood pressure.Frontiers in medicine · 2026Article
- Social Determinants of Health, Blood Pressure Classification, and Incident Stroke Among Chinese Adults.JAMA network open · 2024Article
- Association of hypertension burden with stroke risk in patients with heart failure with preserved ejection fraction.Heliyon · 2024Article
- Article
- Risk reduction intervention for raised blood pressure (REVERSE): protocol for a mixed-methods feasibility study.BMJ open · 2023Article
- Associations between TyG-BMI and normal-high blood pressure values and hypertension: cross-sectional evidence from a non-diabetic population.Frontiers in cardiovascular medicine · 2023Article
- Concordance of recommendations across clinical practice guidelines for the management of hypertension in Southeast Asia with internationally reputable sources.BMC cardiovascular disorders · 2021Article
- The Non-linear Relationship Between Normal Range Systolic Blood Pressure and Cardiovascular or All-Cause Mortality Among Elderly Population.Frontiers in cardiovascular medicine · 2021Article
- The association of stage 1 hypertension defined by the 2017 ACC/AHA hypertension guideline and subsequent cardiovascular events among adults <50 years.Journal of human hypertension · 2020Article
- Impact of new hypertension guidelines on target organ damage screening in a Shanghai community-dwelling population.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Relationship of the Blood Pressure Categories, as Defined by the ACC/AHA 2017 Blood Pressure Guidelines, and the Risk of Development of Cardiovascular Disease in Low-Risk Young Adults: Insights From a Retrospective Cohort of Young Adults.Journal of the American Heart Association · 2019Article
- Management plans for populations with normal-to-hypertensive blood pressures: risks and benefits of antihypertensive drug treatment in populations previously defined as having high-normal blood pressure.The Korean journal of internal medicine · 2019Review
- Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo qualitatively and quantitatively assess the association of prehypertension with incident stroke through a meta-analysis of prospective cohort studies.
methodsWe searched Medline, Embase, the Cochrane Library, and bibliographies of retrieved articles. Prospective cohort studies were included if they reported multivariate-adjusted relative risks (RRs) and corresponding 95%confidence intervals (CI) of stroke with respect to baseline prehypertension.
resultsTwelve studies with 518,520 participants were included. Prehypertension was associated with risk of stroke (RR 1.55, 95% CI 1.35-1.79; p < 0.001). Seven studies further distinguished a low prehypertensive population (systolic blood pressure [SBP] 120-129 mm Hg or diastolic blood pressure [DBP] 80-84 mm Hg) and a high prehypertensive population (SBP 130-139 mm Hg or DBP 85-89 mm Hg). Among persons with lower-range prehypertension, stroke risk was not significantly increased (RR 1.22, 0.95-1.57). However, for persons with higher values within the prehypertensive range, stroke risk was substantially increased (RR 1.79, 95% CI 1.49-2.16).
conclusionsPrehypertension is associated with a higher risk of incident stroke. This risk is largely driven by higher values within the prehypertensive range and is especially relevant in nonelderly persons. Randomized trials to evaluate the efficacy of blood pressure reduction in persons with this designation are warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.