Evidence map›Paper›PMID 21956679›Full record

ReviewHNO2011

[Update on HPV-induced oropharyngeal cancer].

S F Preuss, J-P Klussmann, R Semrau, C Huebbers

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in HNO, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

S F PreussKlinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Kopf-Hals-Chirurgie, Klinikum der Universität zu Köln, Kerpener Str. 62, 50924, Köln, Deutschland. simon.preuss@uni-koeln.de
J-P Klussmann
R Semrau
C Huebbers
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde · DEUniversitätsklinik für Strahlentherapie · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oropharyngeal squamous cell carcinoma (OSCC) is associated with oncogenic human papillomavirus (HPV) infection in 30-40% of all cases in Germany. The use of PCR and / or in situ hybridisation to detect HPV in tumour tissue is used in combination with p16 immunohistochemistry to reliably distinguish HPV-related and HPV-unrelated OSCC. The distinct biological behaviour of the HPV-related subset of OSCC results in a more favourable prognosis. This might be the result of a greater response to chemotherapy and radiotherapy as seen in recent studies. Ongoing and future clinical trials will stratify for HPV status. If the results of these prospective, randomized trials are consistent with the preliminary results of recent studies, HPV status will be of enormous clinical relevance in the future.

Indexed as

Human papillomavirus 16Carcinoma, Squamous CellCombined Modality TherapyDNA Probes, HPVGenes, p16HumansImmunohistochemistryInduction ChemotherapyIn Situ Hybridization, FluorescenceNeoplasm StagingOropharyngeal NeoplasmsPapillomavirus InfectionsPolymerase Chain ReactionPrognosisDNA Probes, HPV

Identifiers

PMID21956679
OpenAlexW2256223414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.