ArticleMolecular and cellular biochemistry2012
Time-sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02370420 (Intra-Articular Injections of Platelet-Rich Plasma in Knee Osteoarthritis), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intra-Articular Injections of Platelet-Rich Plasma in Knee Osteoarthritis: Unique Application Versus Triple Application
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Pooled it
- Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Pooled it
- Platelet-rich plasma in orthopedic therapy: a comparative systematic review of clinical and experimental data in equine and human musculoskeletal lesions.BMC veterinary research · 2015Pooled it
- The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Trial
- Activated platelet rich plasma modulates the proliferation, apoptosis and matrix synthesis driven by growth factors in osteoarthritic chondrocytes: anFrontiers in bioengineering and biotechnology · 2026Article
- Cartilage repair: unleashing PRP's potential in organoid models.Cytotechnology · 2025Review
- Research Progress of Combining High Tibial Osteotomy with Platelet-rich Plasma for Osteoarthritis Therapy.International journal of medical sciences · 2025Review
- Tissue adhesive, ROS scavenging and injectable PRP-based 'plasticine' for promoting cartilage repair.Regenerative biomaterials · 2024Article
- Effect of Platelet-Rich Plasma on Autologous Chondrocyte Implantation for Chondral Defects: Results Using an In Vivo Rabbit Model.Orthopaedic journal of sports medicine · 2022Article
- Role of Triple Injection Platelet-Rich Plasma for Osteoarthritis Knees: A 2 Years Follow-Up Study.Indian journal of orthopaedics · 2022Article
- Biological reconstruction of the joint: Concepts of articular cartilage regeneration and their scientific basis.Journal of clinical orthopaedics and trauma · 2022Review
- Advances in the Treatment of Partial-Thickness Cartilage Defect.International journal of nanomedicine · 2022Review
- Article
- Haemostatic materials for wound healing applications.Nature reviews. Chemistry · 2021Review
- Attenuative Effects of Platelet-Rich Plasma on 30 kDa Fibronectin Fragment-Induced MMP-13 Expression Associated with TLR2 Signaling in Osteoarthritic Chondrocytes and Synovial Fibroblasts.Journal of clinical medicine · 2021Article
- The effectiveness of platelet-rich plasma gel on full-thickness cartilage defect repair in a rabbit model.Bone & joint research · 2021Article
- Cartilage regeneration using a novel autologous growth factors-based matrix for full-thickness defects in sheep.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Platelet‑rich fibrin exudate promotes the proliferation and osteogenic differentiation of human periodontal ligament cells in vitro.Molecular medicine reports · 2018Article
- Platelet-Rich Plasma and Hyaluronic Acid Are Not Synergistic When Used as Biological Adjuncts with Autologous Osteochondral Transplantation.Cartilage · 2018Article
- Therapeutic efficacy of intra-articular hyaluronan derivative and platelet-rich plasma in mice following axial tibial loading.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets are involved in hemostasis, wound healing, and tumor growth. Autologous blood products are commonly used to facilitate healing in a variety of clinical surgery applications. Recently, it was shown that platelet-rich plasma (PRP) has more specific growth factors that participate in the healing process. This study investigated the expression of PRP growth factors and evaluated their potential role in the cartilage regeneration using primary isolated chondrocytes. PRP obtained from New Zealand White rabbit by low speed centrifugation. Extracted PRPs contained 6-10 × 10(6) platelet/μl and concentration of platelets was slightly variable. Primary isolated chondrocytes from the same rabbits were cultured and treated with 0.1-20% PRP. The cells were collected and examined by reverse transcription-polymerase chain reaction and cytochemical staining. The expression of sex determining region Y-box 9, transforming growth factor-beta, vascular endothelial growth factor, and chondromdulin-I was increased in chondrocyte cultures with 10% PRP by time-dependent manner. To maintain the integrity of the cartilage, the proteoglycan contents were also up-regulated from the mRNA of aggrecan and positive Safranin-O staining in PRP concentration- and time-dependent manner. PRP provides crucial growth factors related to chondrocyte proliferation and differentiation through time-sequential modulation. Controlled in vivo trials for cartilage regeneration are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.