ArticleEuropean journal of nutrition2012
Oleic acid inhibits store-operated calcium entry in human colorectal adenocarcinoma cells.
Article in European journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
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- Ufasomes as Topical/Transdermal Drug Delivery System: Structural Components, Preparation Techniques and Therapeutic Application.Current drug delivery · 2025Review
- The effect of FTO gene rs9939609 polymorphism on the association between colorectal cancer and different types of dietary fat intake: a case-control study.Journal of physiological anthropology · 2023Article
- Unveiling the MUFA-Cancer Connection: Insights from Endogenous and Exogenous Perspectives.International journal of molecular sciences · 2023Review
- Oleuropein-Laded Ufasomes Improve the Nutraceutical Efficacy.Nanomaterials (Basel, Switzerland) · 2021Article
- Fatty acid composition and anticancer activity in colon carcinoma cell lines of Prunus dulcis seed oil.Pharmaceutical biology · 2017Article
- Oleic Acid Uptake Reveals the Rescued Enterocyte Phenotype of Colon Cancer Caco-2 by HT29-MTX Cells in Co-Culture Mode.International journal of molecular sciences · 2017Article
- Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40.International journal of molecular sciences · 2017Article
- Effect of oleic acid on store-operated calcium entry in immune-competent cells.European journal of nutrition · 2017Article
- In vitro anti-cancer activities of Job's tears (Coix lachryma-jobi Linn.) extracts on human colon adenocarcinoma.Saudi journal of biological sciences · 2016Article
- STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis.American journal of physiology. Cell physiology · 2015Review
- Nigella Sativa reverses osteoporosis in ovariectomized rats.BMC complementary and alternative medicine · 2014Article
- Nutrient intake and nutrient patterns and risk of lung cancer among heavy smokers: results from the COSMOS screening study with annual low-dose CT.European journal of epidemiology · 2013Article
- Comparison of sterols and fatty acids in two species of Ganoderma.Chemistry Central journal · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsMuch evidence indicates the association between dietary fat and colorectal cancer risk. However, most of the studies focus on polyunsaturated fatty acids, and little is known about the role of monounsaturated ones and their precise mechanism of action. Being store-operated Ca²⁺ entry (SOCE) a Ca²⁺ influx pathway involved in the control of multiple cellular and physiological processes including cell proliferation, we studied the effect of oleic acid in Ca²⁺ signals of colorectal cancer cells, paying particular attention to SOCE.
methodsCarbachol was used to induce SOCE in Fura 2-loaded HT29 cells. We tested a saturated fatty acid to compare the physiological relevance of our results.
resultsWe show that oleic acid is a potent inhibitor of SOCE. By contrast, stearic acid failed to have a SOCE-inhibitory effect. The SOCE-inhibition induced by oleic acid was protein kinase C-independent and restored by albumin. We also demonstrated that oleic acid induced increases in [Ca²⁺](i). The novelty of our report is that little variability in the concentration could end in a large different physiological effect.
conclusionsIn conclusion, we suggest a physiological pathway for the beneficial effect of oleic acid in colon carcinoma cells.
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