ArticleClinical and vaccine immunology : CVI2011
Suppressed type 1, type 2, and type 17 cytokine responses in active tuberculosis in children.
Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Functional and phenotypic characterization of peripheral blood mononuclear cells from tuberculosis patients in Southern Thailand.Frontiers in immunology · 2025Article
- Plasma chemokines as immune biomarkers for diagnosis of pediatric tuberculosis.BMC infectious diseases · 2021Article
- Cytokine Biosignature of Active and Latent Mycobacterium Tuberculosis Infection in Children.Pathogens (Basel, Switzerland) · 2021Article
- Discovery and Validation of a Three-Cytokine Plasma Signature as a Biomarker for Diagnosis of Pediatric Tuberculosis.Frontiers in immunology · 2021Article
- Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada.BMC infectious diseases · 2020Article
- Use of resuscitation promoting factors to screen for tuberculosis infection in household-exposed children in The Gambia.BMC infectious diseases · 2020Article
- Article
- Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection.Clinical and experimental immunology · 2017Article
- Regulatory T Cells and Pro-inflammatory Responses Predominate in Children with Tuberculosis.Frontiers in immunology · 2017Article
- Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases.Frontiers in immunology · 2017Review
- Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment.PloS one · 2017Article
- Disseminated Tuberculosis and Chronic Mucocutaneous Candidiasis in a Patient with a Gain-of-Function Mutation in Signal Transduction and Activator of Transcription 1.Frontiers in immunology · 2017Article
- Evaluation of Interleukin17and Interleukin 23 expression in patients with active and latent tuberculosis infection.Iranian journal of basic medical sciences · 2016Article
- Advances in Drug Discovery and Development for Pediatric Tuberculosis.Mini reviews in medicinal chemistry · 2016Review
- Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins.Oncotarget · 2015Article
- Phosphorylated STAT3 and PD-1 regulate IL-17 production and IL-23 receptor expression in Mycobacterium tuberculosis infection.European journal of immunology · 2014Article
- Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India.Genes and immunity · 2013Article
- Differential cellular recognition pattern to M. tuberculosis targets defined by IFN-γ and IL-17 production in blood from TB + patients from Honduras as compared to health care workers: TB and immune responses in patients from Honduras.BMC infectious diseases · 2013Article
- Decreased expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4⁺ T cells and peripheral blood from tuberculosis patients.PloS one · 2013Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Type 1 cytokine responses are known to play an important role in immunity to tuberculosis (TB) in children, although little is known about other factors that might be important. In addition, children are more prone to developing extrapulmonary manifestations of TB than adults. To identify the immune responses important both in control of infection and in extrapulmonary dissemination, we examined mycobacterium-specific cytokine responses of children with pulmonary TB (PTB) and extrapulmonary TB (ETB) and compared them with those of healthy control children (HC). No significant differences were found in the cytokine responses either with no stimulation or following mycobacterial-antigen (Ag) stimulation between children with PTB and ETB. On the other hand, children with active TB compared with HC showed markedly diminished production of type 1 (gamma interferon [IFN-γ] and tumor necrosis factor alpha [TNF-α]), 2 (interleukin 4 [IL-4] and IL-13), and 17 (IL-17A, IL-21, and IL-23)-associated cytokines with no stimulation and in response to mycobacterial antigens. This was not associated with significantly altered production of IL-10 or transforming growth factor β (TGF-β). Among children with ETB, those with neurologic involvement exhibited more significantly diminished Ag-driven IFN-γ and IL-17 production. Pediatric TB is characterized by diminished type 1, 2, and 17 cytokine responses, with the most profound diminution favoring development of neurologic TB, suggesting a crucial role for these cytokines in protection against pediatric tuberculosis.
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