ArticleAnnals of intensive care2011
Sleep quality in mechanically ventilated patients: comparison between NAVA and PSV modes.
Article in Annals of intensive care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Neurally adjusted ventilatory assist as a weaning mode for adults with invasive mechanical ventilation: a systematic review and meta-analysis.Critical care (London, England) · 2021Pooled it
- A randomized clinical trial of neurally adjusted ventilatory assist versus conventional weaning mode in patients with COPD and prolonged mechanical ventilation.International journal of chronic obstructive pulmonary disease · 2016Trial
- Patient-ventilator synchrony and sleep quality with proportional assist and pressure support ventilation.Intensive care medicine · 2013Trial
- Let's get in sync: current standing and future of AI-based detection of patient-ventilator asynchrony.Intensive care medicine experimental · 2025Review
- Effect of sleep quality on weaning from mechanical ventilation: A scoping review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Review
- Pressure support, patient effort and tidal volume: a conceptual model for a non linear interaction.Critical care (London, England) · 2024Review
- Article
- Optimizing Invasive Neonatal Respiratory Care: A Systematic Review of Invasive Neurally Adjusted Ventilatory Assist.Healthcare (Basel, Switzerland) · 2024Review
- Sleep during and following critical illness: A narrative review.World journal of critical care medicine · 2023Review
- Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023Article
- Updated Perspectives on the Management of Sleep Disorders in the Intensive Care Unit.Nature and science of sleep · 2021Review
- Proportional modes of ventilation: technology to assist physiology.Intensive care medicine · 2020Review
- [Sleep in the intensive care unit].Somnologie : Schlafforschung und Schlafmedizin = Somnology : sleep research and sleep medicine · 2020Review
- Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?Frontiers in neurology · 2020Review
- Correlation between APACHE III score and sleep quality in ICU patients.The Journal of international medical research · 2019Observational
- The effects of mechanical ventilation on the quality of sleep of hospitalised patients in the Intensive Care Unit.Romanian journal of anaesthesia and intensive care · 2018Review
- Sleep quality and circadian rhythm disruption in the intensive care unit: a review.Nature and science of sleep · 2017Review
- Positive and negative effects of mechanical ventilation on sleep in the ICU: a review with clinical recommendations.Intensive care medicine · 2016Review
- Inactivity-induced respiratory plasticity: protecting the drive to breathe in disorders that reduce respiratory neural activity.Respiratory physiology & neurobiology · 2013Review
- Neurally adjusted ventilatory assist: letting the respiratory center take over control of ventilation.Intensive care medicine · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent patient-ventilator asynchronies and more specifically with modes of ventilation. The quality of sleep among ventilated patients seems to be related in part to the alteration between the capacities of the ventilator to meet patient demand. The objective of this study was to compare the impact of two modes of ventilation and patient-ventilator interaction on sleep architecture.
methodsProspective, comparative crossover study in 14 conscious, nonsedated, mechanically ventilated adults, during weaning in a university hospital medical intensive care unit. Patients were successively ventilated in a random ordered cross-over sequence with neurally adjusted ventilatory assist (NAVA) and pressure support ventilation (PSV). Sleep polysomnography was performed during four 4-hour periods, two with each mode in random order.
resultsThe tracings of the flow, airway pressure, and electrical activity of the diaphragm were used to diagnose central apneas and ineffective efforts. The main abnormalities were a low percentage of rapid eye movement (REM) sleep, for a median (25th-75th percentiles) of 11.5% (range, 8-20%) of total sleep, and a highly fragmented sleep with 25 arousals and awakenings per hour of sleep. Proportions of REM sleep duration were different in the two ventilatory modes (4.5% (range, 3-11%) in PSV and 16.5% (range, 13-29%) during NAVA (p = 0.001)), as well as the fragmentation index, with 40 ± 20 arousals and awakenings per hour in PSV and 16 ± 9 during NAVA (p = 0.001). There were large differences in ineffective efforts (24 ± 23 per hour of sleep in PSV, and 0 during NAVA) and episodes of central apnea (10.5 ± 11 in PSV vs. 0 during NAVA). Minute ventilation was similar in both modes.
conclusionsNAVA improves the quality of sleep over PSV in terms of REM sleep, fragmentation index, and ineffective efforts in a nonsedated adult population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.