ArticleInfluenza and other respiratory viruses2012
Respiratory viruses in children with cystic fibrosis: viral detection and clinical findings.
Article in Influenza and other respiratory viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Pooled it
- Article
- Metagenomic next-generation sequencing for detecting lower respiratory tract infections in sputum and bronchoalveolar lavage fluid samples from children.Frontiers in cellular and infection microbiology · 2023Article
- Crosslink between SARS-CoV-2 replication and cystic fibrosis hallmarks.Frontiers in microbiology · 2023Review
- Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection.Immunology and cell biology · 2022Article
- Divergent dynamics of inflammatory mediators and multiplex PCRs during airway infection in cystic fibrosis patients and healthy controls: Serial upper airway sampling by nasal lavage.Frontiers in immunology · 2022Article
- The role of rhinovirus infections in young children with cystic fibrosis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia.International journal of pediatrics & adolescent medicine · 2020Article
- Clinical impact of respiratory virus in pulmonary exacerbations of children with Cystic Fibrosis.PloS one · 2020Article
- Cystic Fibrosis: Fighting Together Against Coronavirus Infection.Frontiers in medicine · 2020Article
- Early respiratory viral infections in infants with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2019Observational
- Viral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study.Virology journal · 2019Article
- Testing the neutral theory of biodiversity with the microbiome dataset from cystic fibrosis patients.Medicine · 2018Observational
- Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies.Frontiers in pharmacology · 2018Review
- Cystic Fibrosis Pulmonary Exacerbations Attributable to Respiratory Syncytial Virus and Influenza: A Population-Based Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Multiplex PCR reveals that viruses are more frequent than bacteria in children with cystic fibrosis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
- Influenza Virus Detection Following Administration of Live-Attenuated Intranasal Influenza Vaccine in Children With Cystic Fibrosis and Their Healthy Siblings.Open forum infectious diseases · 2016Article
- Review
- Rhinovirus Load Is High despite Preserved Interferon-β Response in Cystic Fibrosis Bronchial Epithelial Cells.PloS one · 2015Article
- Detection of respiratory viruses in sputum from adults by use of automated multiplex PCR.Journal of clinical microbiology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundViral detection from different respiratory sample types in children with cystic fibrosis (CF) is facilitated by available molecular methods, but optimum sampling strategies have not been identified. In addition, associations between viral detection and respiratory symptoms are not well described.
objectivesStudy goals were to compare molecular detection of viruses from concurrent upper airway and sputum samples in children with CF and to describe relative frequency of respiratory viral infections and identify potential clinical associations.
methodsWe conducted a 2-year prospective surveillance study in 44 children with CF aged 6-18 years. Upper airway and sputum samples were collected quarterly and during pulmonary exacerbations and tested for respiratory syncytial virus (RSV), influenza viruses, parainfluenza viruses types 1-4, human metapneumovirus, coronaviruses, rhinoviruses, and adenoviruses. Physical exams and symptom surveys were used to identify respiratory signs and symptoms.
resultsUpper airway samples were collected at 359 visits; concordance of PCR-based viral detection was examined in a subset of paired upper airway and sputum samples from 21 participants at 92 visits. Rhinovirus was the most commonly detected virus (23·1% overall), and rhinovirus detection was the same for both sample types (21·7% each). Sensitivity and specificity for the detection of rhinovirus in sputum relative to upper airway sampling were 70% and 91·7%, respectively. Respiratory symptoms associated with rhinovirus detection included increased cough, increased nasal congestion, increased sputum production, and wheezing.
conclusionsA relatively high frequency of rhinovirus detection was observed by either upper airway or sputum samples, and clinical findings suggest a significant-associated symptom burden.
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