Evidence map›Paper›PMID 21955240›Full record

ReviewExpert review of respiratory medicine2011

Recent advances in optical coherence tomography for the diagnoses of lung disorders.

Randy Hou, Tho Le, Septimiu D Murgu, Zhongping Chen, Matt Brenner

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of respiratory medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Optical coherence tomography in the emergency department setting: a case series.American journal of ophthalmology case reports · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Endoscope Capsules: The Present Situation and Future Outlooks.Bioengineering (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Review
  11. A review of low-cost and portable optical coherence tomography.Progress in biomedical engineering (Bristol, England) · 2021
    Article
  12. Article
  13. Imaging in alpha-1 antitrypsin deficiency: a window into the disease.Therapeutic advances in chronic disease · 2021
    Review
  14. Article
  15. Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy.Journal of bronchology & interventional pulmonology · 2018
    Article
  16. In vivo X-Ray Phase Imaging.EBioMedicine · 2015
    Article
  17. Diagnosing lung carcinomas with optical coherence tomography.Annals of the American Thoracic Society · 2015
    Article
  18. Multimodality molecular imaging of the lung.Clinical and translational imaging · 2014
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Randy HouPulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, CA, USA.
Tho Le
Septimiu D Murgu
Zhongping Chen
Matt Brenner
University of California, Irvine · USBeckman Laser Institute and Medical Clinic · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
High Resolution Optical Coherence Tomography for Early Airway Cancer DetectionR01CA124967 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRENNER, MATTHEW · 2007 to 2011
$1.3M
NCI NIH HHS CA 124967NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA124967
6 · The paper itself

Abstract

There have been many advances in the field of diagnostic and therapeutic pulmonary medicine in the past several years, with major progress in the field of imaging. Optical coherence tomography (OCT) is a high-resolution (micron level) imaging modality currently being advanced with the potential to image airway wall structures in real time and at higher resolution than previously possible. OCT has the potential to increase the sensitivity and specificity of biopsies, create 3D images of the airway to guide diagnostics, and may have a future role in diverse areas such as the evaluation and treatment of patients with obstructive sleep apnea, tracheal stenosis, airway remodeling and inhalation injury. OCT has recently been investigated to monitor airway compliance in chronic obstructive pulmonary disease and asthma patients as well as differentiate causes of pulmonary hypertension. In future clinical and research applications, OCT will likely be combined with other endoscopic based modalities such as ultrasound, spectroscopy, confocal, and/or photoacoustic tomography to determine functional and biomolecular properties. This article discusses the current uses of OCT, its potential applications, as it relates to specific pulmonary diseases, and the future directions for OCT.

Indexed as

Tomography, Optical CoherenceBiopsyHumansLungLung DiseasesPredictive Value of TestsPrognosis

Identifiers

PMID21955240
PMCPMC3393648
OpenAlexW2135859966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.