ReviewExpert review of neurotherapeutics2011
An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults.
Review in Expert review of neurotherapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of EEG neurofeedback in adults with attention-deficit/hyperactivity disorder: a systematic review of randomised and non-randomised studies.Journal of neurodevelopmental disorders · 2026Pooled it
- Treatment Outcomes With Licensed and Unlicensed Stimulant Doses for Adults With Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.JAMA psychiatry · 2024Pooled it
- Behavioural effects of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis protocol.BMJ open science · 2018Pooled it
- Microstate-based Neurofeedback in Attention Deficit Hyperactivity Disorder Population: A Randomized Controlled Crossover Trial.Brain topography · 2025Trial
- Open-label dose optimization of methylphenidate modified release long acting (MPH-LA): a post hoc analysis of real-life titration from a 40-week randomized trial.Clinical drug investigation · 2014Trial
- Does pharmacological treatment of ADHD in adults enhance parenting performance? Results of a double-blind randomized trial.CNS drugs · 2014Trial
- Methylphenidate for attention deficit hyperactivity disorder and drug relapse in criminal offenders with substance dependence: a 24-week randomized placebo-controlled trial.Addiction (Abingdon, England) · 2014Trial
- Long-term functional outcome in adult prison inmates with ADHD receiving OROS-methylphenidate.European archives of psychiatry and clinical neuroscience · 2012Trial
- Personality Pathology and Functional Outcomes During Pharmacological Treatment of Adult ADHD.Personality and mental health · 2026Article
- Factors Associated with Reduced Clinical Response in Adult ADHD: The Role of Alcohol and Cannabis Use Disorders and Autism Spectrum Disorder.Journal of clinical medicine · 2026Article
- Cardiovascular Risk Associated with the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults.Current cardiology reports · 2025Review
- Attention-deficit/hyperactivity disorder (ADHD) in adults: a multilayered approach to a serious disorder of inattention to the future.Arquivos de neuro-psiquiatria · 2024Review
- Structural and functional perspectives on interactions between synthetic cathinones and monoamine transporters.Advances in pharmacology (San Diego, Calif.) · 2024Article
- Modafinil, an atypical CNS stimulant?Advances in pharmacology (San Diego, Calif.) · 2024Article
- Functional Impairments Associated With ADHD in Adulthood and the Impact of Pharmacological Treatment.Journal of attention disorders · 2023Review
- Gaze-based attention refocusing training in virtual reality for adult attention-deficit/hyperactivity disorder.BMC psychiatry · 2023Article
- Alpha modulation via transcranial alternating current stimulation in adults with attention-deficit hyperactivity disorder.Frontiers in psychology · 2023Review
- Management of ADHD in Prisoners-Evidence Gaps and Reasons for Caution.Frontiers in psychiatry · 2022Article
- ADHD and offending.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Development of an innovative adult attention-deficit hyperactivity disorder clinic.The mental health clinician · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Adults with attention-deficit/hyperactivity disorder (ADHD) are more frequently presenting for diagnosis and treatment. Medication is considered to be appropriate among available treatments for ADHD; however, the evidence supporting the use of pharmacotherapeutics for adults with ADHD remains less established. In this article, the effectiveness and dosing parameters of the various agents investigated for adult ADHD are reviewed. In adults with ADHD, short-term improvements in symptomatology have been documented through the use of stimulants and antidepressants. Studies suggest that methylphenidate and amphetamine maintained an immediate onset of action, whereas the ADHD response to the nonstimulants appeared to be delayed. At a group level, there appears to be some, albeit not entirely consistent, dose-dependent responses to amphetamine and methylphenidate. Generally speaking, variability in diagnostic criteria, dosing parameters and response rates between the various studies was considerable, and most studies were of a relatively short duration. The aggregate literature shows that the stimulants and catecholaminergic nonstimulants investigated had a clinically significant beneficial effect on treating ADHD in adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.