ArticleBritish journal of pharmacology2012
TLR4-MyD88 signalling: a molecular target for alcohol actions.
Article in British journal of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.Food science & nutrition · 2025Article
- Alcohol, inflammation, and blood-brain barrier function in health and disease across development.International review of neurobiology · 2022Review
- Binge-like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex.Genes, brain, and behavior · 2021Article
- Identification of Potential Biomarkers in the Cervicovaginal Fluid by Metabolic Profiling for Preterm Birth.Metabolites · 2020Article
- Toll-Like Receptor 4 Signaling and Drug Addiction.Frontiers in pharmacology · 2020Review
- Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages.EBioMedicine · 2019Article
- Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain.Scientific reports · 2019Article
- Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.Journal of neuroinflammation · 2018Article
- Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity.Brain, behavior, and immunity · 2018Article
- The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis.Biological psychiatry · 2016Article
- Persistent adaptation by chronic alcohol is facilitated by neuroimmune activation linked to stress and CRF.Alcohol (Fayetteville, N.Y.) · 2016Review
- Article
- The epigenetic landscape of alcoholism.International review of neurobiology · 2014Review
- Expression and significance of HMGB1, TLR4 and NF-κB p65 in human epidermal tumors.BMC cancer · 2013Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Several studies implicate Toll-like receptors (TLRs) in alcohol-induced neuroinflammatory processes. The work reported by Wu et al., in this issue of the British Journal of Pharmacology, indicates that TLR4 along with its intracellular adaptor protein, MyD88, may play crucial roles in the acute actions of alcohol. The deletions of TLR4 or MyD88 gene or pharmacological inhibition of TLR4 by (+)-naloxone were able to attenuate alcohol-induced sedation, motor impairment and acute alcohol-induced increases in IkBα protein levels in the hippocampus of mice. These results clearly suggest that TLR4-MyD88 signalling may play a causal role in the mediation of the behavioural effects of acute alcohol.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.