ArticleInternational journal of molecular sciences2011
Antioxidant, antimicrobial and antiproliferative activities of five lichen species.
Article in International journal of molecular sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of lichen secondary metabolites on Aspergillus fungi.Archives of microbiology · 2021Pooled it
- Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges.Biomedicines · 2026Review
- Unveiling Lichen's Hidden Arsenal Against Multidrug Resistance: A Systematic Review of Their Essential Oils, Volatile Compounds and Extracts with Antimicrobial Applications.Microorganisms · 2026Review
- Extraction, Characterization and Biological Activities of Selected Lichens Growing in Serbia.Journal of fungi (Basel, Switzerland) · 2026Article
- Antibiotic resistance genes detected in lichens: insights from Cladonia stellaris.Annals of botany · 2026Article
- Extraction of lichen bioactive compounds using volatile natural deep eutectic solvents and comparative analytical approaches.Scientific reports · 2025Article
- Lichen and Its Microbiome as an Untapped Source of Anti-Biofilm Compounds.Chemistry & biodiversity · 2025Review
- Conventional and innovative approaches to black fungi control for stone heritage preservation.IUBMB life · 2025Review
- Eco-Friendly SpeciesACS omega · 2024Article
- Evaluation of the Antifungal and Antiproliferative Properties of the LichenPharmaceutics · 2024Article
- Pleiotropic Potential ofMolecules (Basel, Switzerland) · 2023Article
- Article
- Phytochemical Profile, Antioxidant, Antimicrobial, and Antidiabetic Activities ofLife (Basel, Switzerland) · 2023Article
- Antioxidant and antimicrobial activities and GC/MS-based phytochemical analysis of two traditional Lichen species Trypethellium virens and Phaeographis dendritica.Journal, genetic engineering & biotechnology · 2023Article
- Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution.Frontiers in pharmacology · 2023Article
- Metabolomic Profiling, Antioxidant and Enzyme Inhibition Properties and Molecular Docking Analysis of Antarctic Lichens.Molecules (Basel, Switzerland) · 2022Article
- Colicins and Microcins Produced byInternational journal of environmental research and public health · 2022Review
- UHPLC-MS Metabolomic Fingerprinting, Antioxidant, and Enzyme Inhibition Activities ofMetabolites · 2022Article
- A Comparative Study of Isolated Secondary Metabolites from Lichens and Their Antioxidative Properties.Plants (Basel, Switzerland) · 2022Article
- Elemental Analysis and In Vitro Evaluation of Antibacterial and Antifungal Activities ofPlants (Basel, Switzerland) · 2021Article
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11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antioxidative, antimicrobial and antiproliferative potentials of the methanol extracts of the lichen species Parmelia sulcata, Flavoparmelia caperata, Evernia prunastri, Hypogymnia physodes and Cladonia foliacea were evaluated. The total phenolic content of the tested extracts varied from 78.12 to 141.59 mg of gallic acid equivalent (GA)/g of extract and the total flavonoid content from 20.14 to 44.43 mg of rutin equivalent (Ru)/g of extract. The antioxidant capacities of the lichen extracts were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals scavenging. Hypogymnia physodes with the highest phenolic content showed the strongest DPPH radical scavenging effect. Further, the antimicrobial potential of the lichen extracts was determined by a microdilution method on 29 microorganisms, including 15 strains of bacteria, 10 species of filamentous fungi and 4 yeast species. A high antimicrobial activity of all the tested extracts was observed with more potent inhibitory effects on the growth of Gram (+) bacteria. The highest antimicrobial activity among lichens was demonstrated by Hypogymnia physodes and Cladonia foliacea. Finally, the antiproliferative activity of the lichen extracts was explored on the colon cancer adenocarcinoma cell line HCT-116 by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) viability assay and acridine orange/ethidium bromide staining. The methanol extracts of Hypogymnia physodes and Cladonia foliacea showed a better cytotoxic activity than the other extracts. All lichen species showed the ability to induce apoptosis of HCT-116 cells.
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