ArticleStatistics in medicine2012
Competing risks and the clinical community: irrelevance or ignorance?
Article in Statistics in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis.Malaria journal · 2019Pooled it
- External validation of four dementia prediction models for use in the general community-dwelling population: a comparative analysis from the Rotterdam Study.European journal of epidemiology · 2018Pooled it
- Accounting for competing risks in randomized controlled trials: a review and recommendations for improvement.Statistics in medicine · 2017Pooled it
- Pooled it
- Kaplan-Meier Survival Analysis Overestimates the Risk of Revision Arthroplasty: A Meta-analysis.Clinical orthopaedics and related research · 2015Pooled it
- Guiding principles for the care of older adults with multimorbidity: an approach for clinicians: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity.Journal of the American Geriatrics Society · 2012Guideline
- Patient-centered care for older adults with multiple chronic conditions: a stepwise approach from the American Geriatrics Society: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity.Journal of the American Geriatrics Society · 2012Guideline
- Variable selection methods for predicting clinical outcomes following allogeneic hematopoietic cell transplantation.Scientific reports · 2021Trial
- A Competing-Risk Approach for Modeling Length of Stay in Severe Malaria Patients in South-East Asia and the Implications for Planning of Hospital Services.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Trial
- Trial
- Trial
- A life course perspective on evolving hypertension and diabetes risk among older Indians.BMC public health · 2026Article
- Incidence and Prognostic Indicators of Dementia in Patients With Covert Brain Infarction, Transient Ischemic Attack, and Stroke: The Population-Based Rotterdam Study.Journal of the American Heart Association · 2026Article
- External validation of dementia risk prediction models in the EPIC-Norfolk cohort: a UK-based cohort study.NPJ dementia · 2026Article
- Usefulness of albumin-to-D-dimer ratio in predicting the long-term outcome after hospital discharge in patients with ST-elevation myocardial infarction: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Competing risk analysis of prognosis in patients with uveal melanoma.Discover oncology · 2025Article
- Evaluating the association of transferring governance of correctional health care services with overdose and all-cause mortality: a retrospective cohort study in British Columbia, Canada.Health & justice · 2025Article
- Competing and Noncompeting Risk Models for Predicting Kidney Allograft Failure.Journal of the American Society of Nephrology : JASN · 2025Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Life expectancy has dramatically increased in industrialized nations over the last 200 hundred years. The aging of populations carries over to clinical research and leads to an increasing representation of elderly and multimorbid individuals in study populations. Clinical research in these populations is complicated by the fact that individuals are likely to experience several potential disease endpoints that prevent some disease-specific endpoint of interest from occurrence. Large developments in competing risks methodology have been achieved over the last decades, but we assume that recognition of competing risks in the clinical community is still marginal. It is the aim of this article to address translational aspects of competing risks to the clinical community. We describe clinical populations where competing risks issues may arise. We then discuss the importance of agreement between the competing risks methodology and the study aim, in particular the distinction between etiologic and prognostic research questions. In a review of 50 clinical studies performed in individuals susceptible to competing risks published in high-impact clinical journals, we found competing risks issues in 70% of all articles. Better recognition of issues related to competing risks and of statistical methods that deal with competing risks in accordance with the aim of the study is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.