ArticleJournal of the American Society for Mass Spectrometry2011
Differentiation of α- or β-aspartic isomers in the heptapeptides by the fragments of [M + Na]+ using ion trap tandem mass spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 8 citations in OpenAlex.
- Investigation of bn-44 peptide fragments using high resolution mass spectrometry and isotope labeling.Journal of the American Society for Mass Spectrometry · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrospray ionization coupled with low energy collision induced dissociation (CID) in an ion trap mass spectrometer was used to examine the fragmentation patterns of the [M + Na](+) of eight pairs of heptapeptides containing α- or β-Asp residues in second and sixth amino acid positions, respectively. Selective cleavages at the peptide backbone C-terminal to two Asp residues were observed, which generated a series of C-terminal y(5) ions and N-terminal b(6) ions. Two typical ions: [y5 + Na - H]+ and [b6 + Na + OH]+, produced by α-Asp containing peptides were noted to be much more abundant than those of the peptides with β-Asp, which could be used for distinction of the isomers in Asp2 and Asp6, respectively. In addition, a series of internal ions generated by simultaneous cleavages at Asp residues were detected. Competitive reactions of carboxylic groups occurred between Asp6 side chain and C-terminus. Formation mechanisms of most product ions are proposed. The results obtained in this work are significant since low energy CID has been demonstrated to be effective for the distinction of Asp isomers.
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Registered trials
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