ArticleThe Journal of pathology2012
Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation.
Article in The Journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 78 citations in OpenAlex.
- Innovative 3D-Image Analysis of Cerebellar Vascularization Highlights Angiogenic Gene Dysregulations in a Murine Model of Apnea of Prematurity.Cerebellum (London, England) · 2026Article
- Short- and Long-Term Effects of Sodium Phenylbutyrate on White Matter and Sensorimotor and Cognitive Behavior in a Mild Murine Model of Encephalopathy of Prematurity.International journal of molecular sciences · 2025Article
- Effect of Study-Duration and Time of Day on Multichannel Sleep Study Findings in Former Preterm Infants.Children (Basel, Switzerland) · 2025Article
- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
- Altered fornix integrity is associated with sleep apnea-related hypoxemia in mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Review
- Hypoxic White Matter Injury and Recovery After Reoxygenation in Adult Mice: Magnetic Resonance Imaging Findings and Histological Studies.Cellular and molecular neurobiology · 2023Article
- Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker.Frontiers in psychiatry · 2023Review
- Apnea of prematurity induces short and long-term development-related transcriptional changes in the murine cerebellum.Current research in neurobiology · 2023Article
- Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits.Cell & bioscience · 2022Article
- Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- PGC-1α activity and mitochondrial dysfunction in preterm infants.Frontiers in physiology · 2022Review
- Pharmacodynamic Effects of Standard versus High Caffeine Doses in the Developing Brain of Neonatal Rats Exposed to Intermittent Hypoxia.International journal of molecular sciences · 2021Article
- Occlusion of activity dependent synaptic plasticity by late hypoxic long term potentiation after neonatal intermittent hypoxia.Experimental neurology · 2021Review
- Signs of Chronic Hypoxia Suggest a Novel Pathophysiological Event in α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury.The Journal of clinical investigation · 2020Article
- Experimentally Induced Sepsis Causes Extensive Hypomyelination in the Prefrontal Cortex and Hippocampus in Neonatal Rats.Neuromolecular medicine · 2020Article
- Metallothionein induction attenuates the progression of lung injury in mice exposed to long-term intermittent hypoxia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Immediate and delayed decrease of long term potentiation and memory deficits after neonatal intermittent hypoxia.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Article
- Combination of Broccoli Sprout Extract and Zinc Provides Better Protection against Intermittent Hypoxia-Induced Cardiomyopathy Than Monotherapy in Mice.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Premature babies are at high risk for both infantile apnoea and long-term neurobehavioural deficits. Recent studies suggest that diffuse structural changes in brain white matter are a positive predictor of poor cognitive outcomes. Since oligodendrocyte maturation, myelination, axon development, and synapse formation mainly occur in the third trimester of gestation and first postnatal year, infantile apnoea could lead to and/or exaggerate white matter impairments in preterm neonates. Therefore, we investigated oligodendroglia and axon development in a neonatal mouse model of intermittent hypoxia between postnatal days 2 and 10. During critical phases of central nervous system development, intermittent hypoxia induced hypomyelination in the corpus callosum, striatum, fornix, and cerebellum, but not in the pons or spinal cord. Intermittent hypoxia-elicited alterations in myelin-forming processes were reflected by decreased expression of myelin proteins, including MBP, PLP, MAG, and CNPase, possibly due to arrested maturation of oligodendrocytes. Ultrastructural abnormalities were apparent in the myelin sheath and axon. Immature oligodendrocytes were more vulnerable to neonatal intermittent hypoxia exposures than developing axons, suggesting that hypomyelination may contribute, at least partially, to axonal deficits. Insufficient neurofilament synthesis with anomalous components of neurofilament subunits, β-tubulin, and MAP2 isoforms indicated immaturity of axons in intermittent hypoxia-exposed mouse brains. In addition, down-regulation of synapsin I, synaptophysin, and Gap-43 phosphorylation suggested a potential stunt in axonogenesis and synaptogenesis. The region-selective and complex impairment in brain white matter induced by intermittent hypoxia was further associated with electrophysiological changes that may underlie long-term neurobehavioural sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.