ArticleJournal of the American Society for Mass Spectrometry2011
Expansion cooling in the matrix plume is under-recognized in MALDI mass spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 38 citations in OpenAlex.
- Influence of Acceleration Field and Inlet Temperature on Ion Yields of Small Molecules in Atmospheric Pressure MALDI.International journal of mass spectrometry · 2026Article
- Internal Energy Deposition in Infrared Matrix-Assisted Laser Desorption Electrospray Ionization With and Without the Use of Ice as a Matrix.Journal of the American Society for Mass Spectrometry · 2019Article
- Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry: Mechanistic Studies and Methods for Improving the Structural Identification of Carbohydrates.Mass spectrometry (Tokyo, Japan) · 2017Article
- 5-Methoxysalicylic acid matrix for ganglioside analysis with matrix-assisted laser desorption/ionization mass spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- Energetics and kinetics of thermal ionization models of MALDI.Journal of the American Society for Mass Spectrometry · 2014Article
- Thermal proton transfer reactions in ultraviolet matrix-assisted laser desorption/ionization.Journal of the American Society for Mass Spectrometry · 2014Article
- Efficient methods to generate reproducible mass spectra in matrix-assisted laser desorption ionization of peptides.Journal of the American Society for Mass Spectrometry · 2013Article
- A mechanism for ionization of nonvolatile compounds in mass spectrometry: considerations from MALDI and inlet ionization.Journal of the American Society for Mass Spectrometry · 2012Article
- Degree of ionization in MALDI of peptides: thermal explanation for the gas-phase ion formation.Journal of the American Society for Mass Spectrometry · 2012Article
- Ion yields for some salts in MALDI: mechanism for the gas-phase ion formation from preformed ions.Journal of the American Society for Mass Spectrometry · 2012Article
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3 authors at 2 institutions in 1 country.
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Abstract
Time-of-flight (TOF) mass spectra for a peptide (Y(6)) were obtained by utilizing matrix-assisted infrared laser desorption ionization (IR-MALDI) with glycerol as the matrix and by ultraviolet MALDI with α-cyano-4-hydroxycinnamic acid (CHCA), sinapinic acid (SA), and 2,5-dihydroxybenzoic acid (DHB). Collisional activation during ion extraction and exothermicity in the gas-phase proton transfer were found to be unimportant as the driving forces for in-source (ISD) and post-source (PSD) decays, indicating that the thermal energy acquired during photo-ablation is responsible for their occurrence. The temperatures of [Y(6) + H](+) in the 'early' and 'late' matrix plumes were estimated by the kinetic analysis of the ISD and PSD yields, respectively. The order of the temperatures was glycerol < DHB ≈ SA < CHCA in the early plume and glycerol < DHB < SA < CHCA in the late plume. For each matrix, the temperature in the late plume was lower than in the early plume by 300-400 K, which was attributed to expansion cooling. The model (thermalization followed by expansion cooling) proposed to explain the occurrence of both rapid ISD and slow PSD is not only in sharp contrast with but also mutually exclusive with the prevailing explanation that the exothermicity in proton transfer and in-plume collisional activation are the driving forces for ion fragmentation in MALDI. The model also explains why MALDI is more successful for mass spectrometry of labile molecules than other desorption techniques that do not utilize a matrix. Factors affecting the plume temperature are also discussed.
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