ArticleJournal of the American Society for Mass Spectrometry2011
Production of reliable MALDI spectra with quality threshold clustering of replicates.
Article in Journal of the American Society for Mass Spectrometry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Alfred L. Yergey III (September 17, 1941-May 27, 2018).Journal of the American Society for Mass Spectrometry · 2019Article
- Mass spectrometry imaging of lipids: untargeted consensus spectra reveal spatial distributions in Niemann-Pick disease type C1.Journal of lipid research · 2018Article
- BRAF pyrosequencing analysis aided by a lookup table.American journal of clinical pathology · 2014Article
- Comprehensive analysis of LC/MS data using pseudocolor plots.Journal of the American Society for Mass Spectrometry · 2013Article
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Authors and funding
4 authors.
Funding
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Abstract
We present the first application of the quality threshold (QT) clustering algorithm to mass spectrometry (MS) data. The unique abilities of QT clustering to yield precision nodes that are commensurate with the mass measurement precision of the instrument are exploited to generate a consensus spectrum out of multiple replicate spectra. The spectral dot product and confidence intervals are used as a tool for evaluating the similarity and reproducibility between the consensus and replicates. The method is equally applicable to high and low resolution measurements. This paper demonstrates applications to linear spectra from a matrix assisted laser desorption ionization (MALDI) time of flight (TOF) instrument as well as peptide fragmentation data obtained from a TOF/TOF after unimolecular decomposition. The advantages of clustering to mitigate the inherent precision the shortcomings of MALDI data are discussed.
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Registered trials
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