ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2011
Unusual augmentation of germline genome size in Cyclops kolensis (Crustacea, Copepoda): further evidence in support of a revised model of chromatin diminution.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Chromatin diminution as a tool to study some biological problems.Comparative cytogenetics · 2024Article
- Study of chromatin diminution inComparative cytogenetics · 2021Article
- An epigenetic toolkit allows for diverse genome architectures in eukaryotes.Current opinion in genetics & development · 2015Review
- Billions of basepairs of recently expanded, repetitive sequences are eliminated from the somatic genome during copepod development.BMC genomics · 2014Article
- Chromatin diminution in Copepoda (Crustacea): pattern, biological role and evolutionary aspects.Comparative cytogenetics · 2014Article
- Observing copepods through a genomic lens.Frontiers in zoology · 2011Article
- EMBRYONIC DEVELOPMENT AND A QUANTITATIVE MODEL OF PROGRAMMED DNA ELIMINATION INJournal of crustacean biology : a quarterly of the Crustacean Society for the publication of research on any aspect of the biology of crustaceaArticle
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3 authors at 2 institutions in 1 country.
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Abstract
Embryonic chromatin diminution, the selective excision of large amounts of heterochromatic DNA from presomatic cell lineages, provides an example of an unusually large augmentation of the germline genome and raises questions regarding the source of the increased amount of DNA and its relevance to the biology of the organism. DNA levels in adult germ cell nuclei of the copepod Cyclops kolensis were determined by DNA-Feulgen cytophotometry and compared with those of somatic nuclei of adults and both pre- and postdiminuted embryos from the same mothers. Almost 75 pg DNA/nucleus is excised by diminution, resulting in the return of each generation to the approximately 1 pg DNA/nucleus level found for adult soma. To account for the increase in DNA levels of germ cells observed here, we propose alternative hypotheses to the original model of chromatin diminution: (1) repetitive endocycles or (2) proliferation of genetic elements. Specific tests for these hypotheses using next-generation sequencing and quantitative cytophotometry, as well as the functional significance of germ cell DNA augmentation to the copepod, are discussed.
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