ArticleJournal of neuro-oncology2012
Predictors of survival among older adults with ependymoma.
Article in Journal of neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Long-term outcomes after adjuvant radiotherapy in adult spinal ependymomas: a multicenter study by the trod Neuro-Oncology research group (07 - 005).Journal of neuro-oncology · 2026Article
- Surgical Intervention in Very Elderly Patients with Spinal Ependymoma: A National Cancer Database Analysis.Cancers · 2026Article
- Clinical Features and Prognostic Indicators for Brainstem Ependymomas : A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.Journal of Korean Neurosurgical Society · 2026Article
- Optimizing outcomes in intracranial ependymoma: a contemporary review.Frontiers in oncology · 2025Review
- Imaging of supratentorial ependymomas with radio-pathological correlation.Exploration of targeted anti-tumor therapy · 2024Article
- Do We Need Radiotherapy in Grade II Ependymoma?Frontiers in oncology · 2022Article
- Cerebellopontine angle ependymoma presenting as isolated hearing loss in an elderly patient: A case report and literature review.Surgical neurology international · 2021Article
- Ependymoma, NOS and anaplastic ependymoma incidence and survival in the United States varies widely by patient and clinical characteristics, 2000-2016.Neuro-oncology practice · 2020Article
- The effect of adjuvant radiotherapy on overall survival in adults with intracranial ependymoma.Neuro-oncology practice · 2020Article
- Found at Old Age and Continuously Growing WHO Grade II Fourth Ventricle Ependymoma: A Case Report.Brain tumor research and treatment · 2019Article
- Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients.Neuro-oncology · 2015Article
- Supratentorial extraventricular anaplastic ependymoma in an adult with repeated intratumoral hemorrhage.Brain tumor pathology · 2014Review
- Natural history and role of radiation in patients with supratentorial and infratentorial WHO grade II ependymomas: results from a population-based study.Journal of neuro-oncology · 2013Article
- Histological predictors of outcome in ependymoma are dependent on anatomic site within the central nervous system.Brain pathology (Zurich, Switzerland) · 2013Article
- A multi-center retrospective analysis of treatment effects and quality of life in adult patients with cranial ependymomas.Journal of neuro-oncology · 2013Article
- Descriptive epidemiology of ependymal tumours in the United States.British journal of cancer · 2013Article
- Anaplastic supratentorial cortical ependymoma presenting as a butterfly lesion.Surgical neurology international · 2012Article
- Comparison of epidemiology, treatments, and outcomes in pediatric versus adult ependymoma.Neuro-oncology advancesArticle
- World Health Organization Grade III Supratentorial Extraventricular Ependymomas in Adults: Case Series and Review of Treatment Modalities.Asian journal of neurosurgeryArticle
- Adult Supratentorial Extraventricular Anaplastic Ependymoma: Therapeutic Approach and Clinical Review.Asian journal of neurosurgeryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The biological process of aging encompasses a multitude of complex physiological and lifestyle changes that may alter the way typical prognostic factors affect survival among older ependymoma patients. Because very little is known about the clinical significance of traditional prognostic factors and the magnitude of their effects among older individuals, the purpose of this study was to evaluate the associations between survival and demographic and tumor characteristics among patients with ependymoma who were 60 years of age or older. Using the 1973-2007 dataset from the Surveillance, Epidemiology and End Results (SEER) program, we evaluated the impact of several factors on both overall and ependymoma-specific survival, utilizing multivariable Cox proportional hazards regression. We identified 367 ependymoma cases who were 60 years of age or older at diagnosis and had complete data from SEER. Of these, 19 (5.2%) had anaplastic tumors; all others were low-grade tumors. Age, tumor site, extent of surgery, and tumor histology were found to be significant predictors of ependymoma prognosis. The strongest predictor of poor outcome was supratentorial tumor location (adjusted HR: 6.94, 95% CI: 3.19-15.08, compared to spinal cord tumors). Our study suggests that tumor location, tumor histology, and surgical margin may be key predictors of survival among older ependymoma patients. We believe our study is one of the first to assess the prognostic value of these factors for ependymoma survival exclusively in an older patient population.
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