ReviewCellular and molecular life sciences : CMLS2011
Establishment of intestinal homeostasis during the neonatal period.
Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Development and functional adaptation of intestinal macrophages across the lifespan.Clinical & translational immunology · 2026Review
- Disrupting and restoring protection: maternal antibiotic exposure and neonatal IgA transfer via breastfeeding.Pediatric research · 2025Article
- Intestinal Models for Personalized Medicine: from Conventional Models to Microfluidic Primary Intestine-on-a-chip.Stem cell reviews and reports · 2022Review
- Developmental intestinal microbiome alterations in canine fading puppy syndrome: a prospective observational study.NPJ biofilms and microbiomes · 2021Article
- Clinical Study of Correlation for the Intestinal and Pharyngeal Microbiota in the Premature Neonates.Frontiers in pediatrics · 2021Article
- Bacterial Gut Microbiota and Infections During Early Childhood.Frontiers in microbiology · 2021Review
- Review
- Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice.Scientific reports · 2019Article
- Impact of Maternal Malnutrition on Gut Barrier Defense: Implications for Pregnancy Health and Fetal Development.Nutrients · 2019Article
- Urbanization and the gut microbiota in health and inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2018Review
- The Gastrointestinal Microbiome: A Review.Journal of veterinary internal medicine · 2018Review
- Review
- Article
- Priority topics for the development of risk assessment guidance by EFSA's Scientific Committee in 2016-2018.EFSA journal. European Food Safety Authority · 2016Article
- How colonization by microbiota in early life shapes the immune system.Science (New York, N.Y.) · 2016Review
- The Gut Microbiota and the Emergence of Autoimmunity: Relevance to Major Psychiatric Disorders.Current pharmaceutical design · 2016Review
- Role of Immune and Autoimmune Dysfunction in Schizophrenia.Handbook of behavioral neuroscience · 2016Article
- Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking.PLoS pathogens · 2015Article
- Rate of establishing the gut microbiota in infancy has consequences for future health.Gut microbes · 2015Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal mucosa faces the challenge of regulating the balance between immune tolerance towards commensal bacteria, environmental stimuli and food antigens on the one hand, and induction of efficient immune responses against invading pathogens on the other hand. This regulatory task is of critical importance to prevent inappropriate immune activation that may otherwise lead to chronic inflammation, tissue disruption and organ dysfunction. The most striking example for the efficacy of the adaptive nature of the intestinal mucosa is birth. Whereas the body surfaces are protected from environmental and microbial exposure during fetal life, bacterial colonization and contact with potent immunostimulatory substances start immediately after birth. In the present review, we summarize the current knowledge on the mechanisms underlying the transition of the intestinal mucosa during the neonatal period leading to the establishment of a stable, life-long host-microbial homeostasis. The environmental exposure and microbial colonization during the neonatal period, and also the influence of maternal milk on the immune protection of the mucosa and the role of antimicrobial peptides, are described. We further highlight the molecular mechanisms of innate immune tolerance in neonatal intestinal epithelium. Finally, we link the described immunoregulatory mechanisms to the increased susceptibility to inflammatory and infectious diseases during the neonatal period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.