ArticleEuropean journal of immunology2011
Revisiting the protective and pathogenic roles of neutrophils: Ly-6G is key!
Article in European journal of immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Neutrophils in cancer: At the crucial crossroads of anti-tumor and pro-tumor.Cancer communications (London, England) · 2025Review
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- Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2-IL-6 axis.Journal of neuroinflammation · 2023Article
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- Immunopathogenesis of Craniotomy Infection and Niche-Specific Immune Responses to Biofilm.Frontiers in immunology · 2021Review
- Next-Generation Immunotherapies to Improve Anticancer Immunity.Frontiers in pharmacology · 2020Review
- Article
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- Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus.PLoS pathogens · 2013Article
- Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.Open biology · 2012Review
- Trial watch: Prognostic and predictive value of the immune infiltrate in cancer.Oncoimmunology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physiological and pathophysiological roles of neutrophils in immune homeostasis and disease have been investigated extensively by way of anti-Gr-1 mAb-mediated depletion experiments; however, the ability of the anti-Gr-1 mAb to specifically deplete neutrophils has long been questioned and it is now known that this mAb, which binds Ly6C and Ly6G, is also able to deplete monocytes and subsets of CD8(+) T cells. This, therefore, casts doubt on the previous conclusions regarding the role of neutrophils drawn from studies using this mAb. Another mAb, which targets Ly6G only, has recently been shown to deplete neutrophils specifically and a study by Carr et al. (Eur. J. Immunol. 2011. 41: 2666-2676) in this issue of the European Journal of Immunology utilizes this Ly-6G mAb to reveal the precise role of neutrophils during Listeria monocytogenes (LM) infection. Carr et al. find that monocytes/macrophages, rather than neutrophils, dominate the initial control of LM growth in the spleen, whereas neutrophils in the liver are key for host resistance to LM infection. These data suggest that the previously reported protective or pathogenic roles of neutrophils in disease models need to be reconsidered through anti-Ly6G mAb-mediated depletion experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.