Evidence map›Paper›PMID 21952693›Full record

Trial reportEuropean journal of clinical nutrition2012

Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial.

M R Wofford, C M Rebholz, K Reynolds, J Chen, C-S Chen, L Myers, J Xu, D W Jones, P K Whelton, J He

2 registry-linked trialsOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00046566 nacompletednot on this map

Clinical Trial of Dietary Protein on Blood Pressure

TypeinterventionalSponsorTulane UniversityRan2002 to 2008Enrolled352ConditionsCardiovascular Diseases, Hypertension, Heart DiseasesArmsSoy protein-milk protein-carbohydrate, Milk protein-carbohydrate-soy protein, Carbohydrate-soy protein-milk protein
NCT00107744 nacompletednot on this map

Clinical Trial of Protein and Blood Pressure

TypeinterventionalSponsorTulane UniversityRan2003 to 2008Enrolled352ConditionsHypertension, HypercholesterolemiaArmsSoy protein-milk protein-carbohydrate, Milk protein-carbohydrate-soy protein, Carbohydrate-soy protein-milk protein
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

M R WoffordDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
C M Rebholz
K Reynolds
J Chen
C-S Chen
L Myers
J Xu
D W Jones
P K Whelton
J He
Tulane University · USJackson Memorial Hospital · USUniversity of Mississippi · US

Funding

Clinical Trial of Dietary Protein on Blood PressureR01HL068057 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2006
$2.9M
NHLBI NIH HHS R01 HL068057NHLBI NIH HHS R01 HL68057
6 · The paper itself

Abstract

BACKGROUND/

objectivePrevious clinical trials have documented that soy protein reduces low-density lipoprotein cholesterol and increases high-density lipoprotein (HDL) cholesterol compared with milk protein. However, the effect of soy protein on lipids compared with carbohydrate has not been not well studied. We examined the effect of soy and milk protein supplementation on lipids and lipoproteins compared with carbohydrate among adults without hypercholesterolemia. SUBJECTS/

methodsWe conducted a randomized, double-blind, 3-phase crossover trial among 352 US adults with serum total cholesterol level of <240 mg/dl from September 2003 to April 2008. Trial participants were assigned to 40 g/day supplementation of soy protein, milk protein or complex carbohydrate from wheat each for 8 weeks in random order with a 3-week washout period between interventions. Overnight fasting blood samples were collected at the termination of each intervention phase.

resultsCompared with carbohydrate, soy protein supplementation was significantly associated with a net change (95% confidence interval (CI)) in total cholesterol and total/HDL cholesterol ratio of -3.97 mg/dl (-7.63 to -0.31, P=0.03) and -0.12 (-0.23 to -0.01, P=0.03), respectively. Compared with milk protein, soy protein supplementation was significantly associated with a net change (95% CI) in HDL and total/HDL cholesterol ratio of 1.54 mg/dl (0.63 to 2.44, P=0.0009) and -0.14 (-0.22 to -0.05, P=0.001), respectively. Compared with carbohydrate, milk protein supplementation was significantly associated with a net change (95% CI) in HDL of -1.13 mg/dl (-2.05 to -0.22, P=0.02).

conclusionsThis randomized controlled trial indicates that soy protein, but not milk protein, supplementation improves the lipid profile among healthy individuals.

Indexed as

Dietary SupplementsAdultCholesterol, HDLCholesterol, LDLCross-Over StudiesDietary CarbohydratesDouble-Blind MethodFemaleHumansHypercholesterolemiaMaleMiddle AgedMilk ProteinsSoybean ProteinsTriglyceridesCholesterol, HDLCholesterol, LDLDietary CarbohydratesMilk ProteinsSoybean ProteinsTriglycerides

Identifiers

PMID21952693
PMCPMC8725017
OpenAlexW1968081326

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.