ArticleBritish journal of cancer2011
HPV in exhaled breath condensate of lung cancer patients.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- HPV and lung cancer: A systematic review and meta-analysis.Cancer reports (Hoboken, N.J.) · 2021Pooled it
- Human papillomavirus and lung cancer: an overview and a meta-analysis.Journal of cancer research and clinical oncology · 2019Pooled it
- High-risk human papillomavirus infection and immunohistochemical expression patterns of p16 and Rb in primary and metastatic squamous cell carcinoma of the lung.Virchows Archiv : an international journal of pathology · 2026Article
- Human papillomavirus infection and its association with lung cancer: a case-control study (2011-2019).Iranian journal of microbiology · 2025Article
- The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges.Advanced genetics (Hoboken, N.J.) · 2025Review
- Article
- Review
- Review of non-invasive detection of SARS-CoV-2 and other respiratory pathogens in exhaled breath condensate.Journal of breath research · 2022Review
- Chemopreventive Role of Apigenin against the Synergistic Carcinogenesis of Human Papillomavirus and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.Biomedicines · 2020Article
- The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue.BMC cancer · 2020Article
- Particle sizes of infectious aerosols: implications for infection control.The Lancet. Respiratory medicine · 2020Review
- Human papillomavirus infection maybe not associated with primary lung cancer in the Fujian population of China.Thoracic cancer · 2020Article
- Bronchial HPV; the good the bad and the unknown.Respiratory medicine case reports · 2020Article
- Possible Oncogenic Viruses Associated with Lung Cancer.OncoTargets and therapy · 2020Review
- Individual and combined effect ofOncotarget · 2018Article
- The association between human papillomavirus infection and lung cancer: a system review and meta-analysis.Oncotarget · 2017Article
- Human papillomavirus and lung cancinogenesis: an overview.Journal of cancer research and clinical oncology · 2016Review
- Molecular analysis of human papillomavirus in never-smokers with non-small cell lung cancer.Oncology letters · 2015Article
- Human papillomavirus infection and risk of lung cancer in never-smokers and women: an 'adaptive' meta-analysis.Epidemiology and health · 2015Review
- Exhaled Breath Condensate: Technical and Diagnostic Aspects.TheScientificWorldJournal · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recent intriguing carcinogenetic hypothesis for lung cancer foresees its viral aetiology. The human papilloma virus (HPV) is the main virus actually recognised in the pathogenesis of lung cancer. The aim of this study was to investigate, for the first time to our knowledge, the presence of HPV in the exhaled breath condensate (EBC) of lung cancer patients. MATERIALS AND
methodWe enrolled 89 patients affected by lung cancer and 68 controls. HPV infections were investigated in their EBC, paired bronchial brushing and neoplastic lung tissue through genotyping.
resultsWe were able to detect HPV in the EBC, bronchial brushing and neoplastic lung tissue. We described the presence of an HPV infection in 16.4% of the subjects affected by non-small cell lung cancer, but in none of the controls. HPV 16 and 31 turned out to be the most widespread genotypes. The HPV positivity in airways as well as in the smoking habit was seen to independently increase the individual's susceptibility to developing lung cancer.
conclusionWhen summing up, we demonstrated the possibility to identify an HPV infection in the EBC of lung cancer patients; further, we supported the notion that the EBC is a suitable tool to study airway colonisation. That being said, although further studies are needed to confirm our results, we retain the study of HPV in EBC to be very interesting in terms of future programmes involving lung-cancer screening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.