ArticleNeonatology2012
Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants.
Article in Neonatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Neutrophil responses to RSV infection show differences between infant and adult neutrophils.Thorax · 2024Article
- Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14International journal of molecular sciences · 2023Article
- Neonatal neutrophils stimulated by group B Streptococcus induce a proinflammatory T-helper cell bias.Pediatric research · 2018Article
- Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Maternal Smoking and Newborn Cytokine and Immunoglobulin Levels.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil.Frontiers in pediatrics · 2017Review
- Animal models of bronchopulmonary dysplasia. The preterm baboon models.American journal of physiology. Lung cellular and molecular physiology · 2014Review
- Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants.Nature medicine · 2014Article
- Intermittent or sustained systemic inflammation and the preterm brain.Pediatric research · 2014Review
- Differential effect of exogenous interleukin-10 versus glucocorticoids on gene expression and pro-inflammatory cytokine release by polymorphonuclear leukocytes and monocytes of the newly born.American journal of translational research · 2013Article
- Gene expression profile of endotoxin-stimulated leukocytes of the term new born: control of cytokine gene expression by interleukin-10.PloS one · 2013Article
- Article
- Elevated acetoacetate and monocyte chemotactic protein-1 levels in cord blood of infants of diabetic mothers.Neonatology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeonatal neutrophil dysfunction contributes to inflammatory tissue damage in newborn infants. Toll-like receptors (TLRs) activate the innate immune response through recognition of pathogen-associated molecular patterns. Expression and function of TLRs by neonatal neutrophils has not well been characterized.
objectiveWe hypothesized that, compared to polymorphonuclear leukocytes (PMNs) isolated from adults, neonatal PMNs isolated from either term or preterm infants express and release different levels of inflammatory cytokines and chemokines in response to stimulation with TLR1-9 agonists.
methodsWe stimulated PMNs isolated from preterm (n = 12) and term (n = 10) infants as well as adults (n = 10) with agonists recognized by TLRs1-9 and quantified chemokine and cytokine expression and secretion by ELISA and Luminex® multiplex quantification assay.
resultsNeonatal and adult PMNs stimulated with agonists recognized by TLRs1-9 differentially secrete inflammatory products. Signaling via TLR2 heterodimers is a potent mechanism for release of interleukin-8, a critical proinflammatory chemokine, by neonatal PMNs--a previously unrecognized facet of neonatal inflammation. Following TLR1/2 (PAM3CSK4) stimulation, interleukin-8 secretion by neonatal PMNs, whether term or preterm, substantially exceeds that of adult PMNs assayed in parallel.
conclusionsThese studies provide new insights relevant to the inflammatory biology of neonates, both term and preterm, and implicate exaggerated PMN recruitment in neonatal syndromes of dysregulated inflammation such as necrotizing enterocolitis or neonatal chronic lung disease.
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