ArticleMolecular systems biology2011
Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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Who cites it
118 citing papers in PubMed, 213 citations in OpenAlex.
- Arabidopsis Heterotrimeric G Beta Variants Shape Plant Development and Modulate Responses to Endoplasmic Reticulum Stress and Salt Stress.Plant, cell & environment · 2026Article
- Linking Superoxide Production and Scavenging in Plant Development.Plant, cell & environment · 2026Review
- Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity.Molecular plant · 2025Article
- Rice grain size: current regulatory mechanisms and future perspectives.Journal of plant research · 2025Review
- Computational exploration ofJournal of biosciences · 2025Article
- The DEP1 Mutation Improves Stem Lodging Resistance and Biomass Saccharification by Affecting Cell Wall Biosynthesis in Rice.Rice (New York, N.Y.) · 2024Article
- Proteomic profiling ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Stomatal responses to VPD utilize guard cell intracellular signaling components.Frontiers in plant science · 2024Article
- Identification of Morphogenesis-Related NDR Kinase Signaling Network and Its Regulation on Cold Tolerance in Maize.Plants (Basel, Switzerland) · 2023Article
- Heterotrimeric G Protein-Mediated Signaling Is Involved in Stress-Mediated Growth Inhibition inInternational journal of molecular sciences · 2023Article
- Cytotrap: An Innovative Approach for Protein-Protein Interaction Studies for Cytoplasmic Proteins.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Dynamic Enrichment for Evaluation of Protein Networks (DEEPN): A High Throughput Yeast Two-Hybrid (Y2H) Protocol to Evaluate Networks.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Preparation and Utilization of a Versatile GFP-Protein Trap-Like System for Protein Complex Immunoprecipitation in Plants.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Building Protein-Protein Interaction Graph Database Using Neo4j.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Protein-Protein Interaction Network Analysis Using NetworkX.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Protein-Protein Interaction Network Exploration Using Cytoscape.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The interplay of GTP-binding protein AGB1 with ER stress sensors IRE1a and IRE1b modulates Arabidopsis unfolded protein response and bacterial immunity.Plant signaling & behavior · 2022Article
- Plant elicitor peptide 1 fortifies root cell walls and triggers a systemic root-to-shoot immune signaling inPlant signaling & behavior · 2022Article
- A pipeline of integrating transcriptome and interactome to elucidate central nodes in host-pathogens interactions.STAR protocols · 2022Article
- Interacting partners of Brassica juncea regulator of G-protein signaling protein suggest its role in cell wall metabolism and cellular signaling.Bioscience reports · 2022Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heterotrimeric G-protein complex is minimally composed of Gα, Gβ, and Gγ subunits. In the classic scenario, the G-protein complex is the nexus in signaling from the plasma membrane, where the heterotrimeric G-protein associates with heptahelical G-protein-coupled receptors (GPCRs), to cytoplasmic target proteins called effectors. Although a number of effectors are known in metazoans and fungi, none of these are predicted to exist in their canonical forms in plants. To identify ab initio plant G-protein effectors and scaffold proteins, we screened a set of proteins from the G-protein complex using two-hybrid complementation in yeast. After deep and exhaustive interrogation, we detected 544 interactions between 434 proteins, of which 68 highly interconnected proteins form the core G-protein interactome. Within this core, over half of the interactions comprising two-thirds of the nodes were retested and validated as genuine in planta. Co-expression analysis in combination with phenotyping of loss-of-function mutations in a set of core interactome genes revealed a novel role for G-proteins in regulating cell wall modification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.