ArticleMolecular plant pathology2012
Ancient diversity of splicing motifs and protein surfaces in the wild emmer wheat (Triticum dicoccoides) LR10 coiled coil (CC) and leucine-rich repeat (LRR) domains.
Article in Molecular plant pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Lessons from Deep Learning Structural Prediction of Multistate Multidomain Proteins-The Case Study of Coiled-Coil NOD-like Receptors.International journal of molecular sciences · 2025Article
- A single NLR gene confers resistance to leaf and stripe rust in wheat.Nature communications · 2024Article
- NLRscape: an atlas of plant NLR proteins.Nucleic acids research · 2023Article
- Candidate powdery mildew resistance gene in wheat landrace cultivar Hongyoumai discovered using SLAF and BSR-seq.BMC plant biology · 2022Article
- NLRexpress-A bundle of machine learning motif predictors-Reveals motif stability underlying plant Nod-like receptors diversity.Frontiers in plant science · 2022Article
- A new comprehensive annotation of leucine-rich repeat-containing receptors in rice.The Plant journal : for cell and molecular biology · 2021Article
- Article
- Wheat Disease Resistance Genes and Their Diversification Through Integrated Domain Fusions.Frontiers in genetics · 2020Article
- Chromosome-based survey sequencing reveals the genome organization of wild wheat progenitor Triticum dicoccoides.Plant biotechnology journal · 2018Article
- Article
- Disease Resistance Mechanisms in Plants.Genes · 2018Review
- Regulation and Evolution of NLR Genes: A Close Interconnection for Plant Immunity.International journal of molecular sciences · 2018Review
- Transcript-level expression control of plant NLR genes.Molecular plant pathology · 2018Review
- Identification and characterization of wheat stem rust resistance gene Sr21 effective against the Ug99 race group at high temperature.PLoS genetics · 2018Article
- Distribution and haplotype diversity of WKS resistance genes in wild emmer wheat natural populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Leucine zipper motif in RRS1 is crucial for the regulation of Arabidopsis dual resistance protein complex RPS4/RRS1.Scientific reports · 2016Article
- An LRR/Malectin Receptor-Like Kinase Mediates Resistance to Non-adapted and Adapted Powdery Mildew Fungi in Barley and Wheat.Frontiers in plant science · 2016Article
- Microscopic and Molecular Characterization of the Prehaustorial Resistance against Wheat Leaf Rust (Frontiers in plant science · 2016Article
- Alternative splicing in plant immunity.International journal of molecular sciences · 2014Review
- Identification of wheat gene Sr35 that confers resistance to Ug99 stem rust race group.Science (New York, N.Y.) · 2013Article
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10 authors.
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Abstract
In this study, we explore the diversity and its distribution along the wheat leaf rust resistance protein LR10 three-dimensional structure. Lr10 is a leaf rust resistance gene encoding a coiled coil-nucleotide-binding site-leucine-rich repeat (CC-NBS-LRR) class of protein. Lr10 was cloned and sequenced from 58 accessions representing diverse habitats of wild emmer wheat in Israel. Nucleotide diversity was very high relative to other wild emmer wheat genes (π= 0.029). The CC domain was found to be the most diverse domain and subject to positive selection. Superimposition of the diversity on the CC three-dimensional structure showed that some of the variable and positively selected residues were solvent exposed and may interact with other proteins. The LRR domain was relatively conserved, but showed a hotspot of amino acid variation between two haplotypes in the ninth repeat. This repeat was longer than the other LRRs, and three-dimensional modelling suggested that an extensive α helix structure was formed in this region. The two haplotypes also differed in splicing regulation motifs. In genotypes with one haplotype, an intron was alternatively spliced in this region, whereas, in genotypes with the other haplotype, this intron did not splice at all. The two haplotypes are proposed to be ancient and maintained by balancing selection.
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