ArticleEnvironmental microbiology2011
Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4.
Article in Environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 82 citations in OpenAlex.
- Ecological plasticity ofMicrobiology spectrum · 2026Article
- The Influence of PVDF Membrane Ageing on the Efficiency of Bacterial Rejection During the Ultrafiltration Treatment of Carwash Wastewater.Materials (Basel, Switzerland) · 2026Article
- HFrontiers in microbiology · 2025Review
- Polyextremophile engineering: a review of organisms that push the limits of life.Frontiers in microbiology · 2024Review
- Desulfatitalea alkaliphila sp. nov., an alkalipilic sulfate- and arsenate- reducing bacterium isolated from a terrestrial mud volcano.Extremophiles : life under extreme conditions · 2023Article
- Multi-Omic Analysis to Characterize Metabolic Adaptation of theMetabolites · 2022Article
- Comparative genome analysis of3 Biotech · 2021Article
- The Development of a Pipeline for the Identification and Validation of Small-Molecule RelA Inhibitors for Use as Anti-Biofilm Drugs.Microorganisms · 2020Article
- Biological Self-Healing of Cement Paste and Mortar by Non-Ureolytic Bacteria Encapsulated in Alginate Hydrogel Capsules.Materials (Basel, Switzerland) · 2020Article
- Nature and bioprospecting of haloalkaliphilics: a review.World journal of microbiology & biotechnology · 2020Review
- Case report: whole genome sequencing based investigation of maternal-neonatal listeriosis in Sichuan, China.BMC infectious diseases · 2019Article
- Influence of Hydrogen Electron Donor, Alkaline pH, and High Nitrate Concentrations on Microbial Denitrification: A Review.International journal of molecular sciences · 2019Review
- A Hydrophobic Small Protein, BpOF4_01690, Is Critical for Alkaliphily of AlkaliphilicFrontiers in microbiology · 2018Article
- Formation of Proton Motive Force Under Low-Aeration Alkaline Conditions in Alkaliphilic Bacteria.Frontiers in microbiology · 2018Review
- A Novel AlkaliphilicFrontiers in microbiology · 2018Article
- The Surface Layer Homology Domain-Containing Proteins of AlkaliphilicFrontiers in microbiology · 2018Article
- Adaptations of archaeal and bacterial membranes to variations in temperature, pH and pressure.Extremophiles : life under extreme conditions · 2017Review
- Comparative metagenomics reveals insights into the deep-sea adaptation mechanism of the microorganisms in Iheya hydrothermal fields.World journal of microbiology & biotechnology · 2017Article
- Floc Formation Reduces the pH Stress Experienced by Microorganisms Living in Alkaline Environments.Applied and environmental microbiology · 2017Article
- Alkaline Response of a Halotolerant Alkaliphilic Halomonas Strain and Functional Diversity of Its Na+(K+)/H+ Antiporters.The Journal of biological chemistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 12 institutions in 7 countries.
Funding
Abstract
Bacillus pseudofirmus OF4 is an extreme but facultative alkaliphile that grows non-fermentatively in a pH range from 7.5 to above 11.4 and can withstand large sudden increases in external pH. It is a model organism for studies of bioenergetics at high pH, at which energy demands are higher than at neutral pH because both cytoplasmic pH homeostasis and ATP synthesis require more energy. The alkaliphile also tolerates a cytoplasmic pH > 9.0 at external pH values at which the pH homeostasis capacity is exceeded, and manages other stresses that are exacerbated at alkaline pH, e.g. sodium, oxidative and cell wall stresses. The genome of B. pseudofirmus OF4 includes two plasmids that are lost from some mutants without viability loss. The plasmids may provide a reservoir of mobile elements that promote adaptive chromosomal rearrangements under particular environmental conditions. The genome also reveals a more acidic pI profile for proteins exposed on the outer surface than found in neutralophiles. A large array of transporters and regulatory genes are predicted to protect the alkaliphile from its overlapping stresses. In addition, unanticipated metabolic versatility was observed, which could ensure requisite energy for alkaliphily under diverse conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.