ReviewCNS neuroscience & therapeutics2011
From hypertension to stroke: mechanisms and potential prevention strategies.
Review in CNS neuroscience & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adherence to the dietary approaches to stop hypertension diet and risk of stroke: A meta-analysis of prospective studies.Medicine · 2018Pooled it
- Association Between Markers of Inflammation and Total Stroke by Hypertensive Status Among Women.American journal of hypertension · 2016Trial
- Combined effects of cumulative triglyceride-glucose and blood pressure on stroke in middle-aged and older Chinese adults: a longitudinal analysis.Journal of global health · 2026Article
- Association between the combined c-reactive protein-triglyceride glucose index and hypertension with long-term stroke among cardiovascular-kidney-metabolic syndrome stages 0-3 population: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Regulating the Impact of Hypertension on Stroke: Therapeutic Potential of a Peptide Mimetic of Tyrosine Phosphatase STEP.Journal of the American Heart Association · 2026Article
- Socio-demographic, behavioral, and biological risk factors of hypertension in Kazakhstan: results of a national study.Population health metrics · 2026Article
- Stroke and associated comorbidities in Southeast Asian countries.Neuroprotection (Chichester, England) · 2025Review
- Article
- Risk Factors for Post-Operative Stroke Following Total Hip Arthroplasty.Orthopedic reviews · 2025Article
- Systemic inflammatory response index mediates the association between stroke and hypertension: a cross-sectional study from NHANES 2001 to 2016.Frontiers in neurology · 2025Article
- Social Determinants of Health, Blood Pressure Classification, and Incident Stroke Among Chinese Adults.JAMA network open · 2024Article
- C-reactive protein-triglyceride glucose index predicts stroke incidence in a hypertensive population: a national cohort study.Diabetology & metabolic syndrome · 2024Article
- Article
- Article
- Hypertension Severity as Quantified by Hypertension Daily Dose and Blood Pressure With Risk of Stroke in REGARDS.Journal of the American Heart Association · 2024Article
- Prevalence and Risk Factors of Stroke in Inpatients with Type 2 Diabetes Mellitus in China.Current medical science · 2024Article
- Interacting and joint effects of triglyceride-glucose index and hypertension on stroke risk in middle-aged and older Chinese adults: a population-based prospective cohort study.Frontiers in cardiovascular medicine · 2024Article
- Accuracy of FAST-ED for Assessment Large Vessel Occlusion of Acute Ischemic Stroke in Emergency Department.Open access emergency medicine : OAEM · 2024Article
- Chronic lead exposure and burden of cardiovascular disease during 1990-2019: a systematic analysis of the global burden of disease study.Frontiers in cardiovascular medicine · 2024Article
- Stroke vs. Preeclampsia: Dangerous Liaisons of Hypertension and Pregnancy.Medicina (Kaunas, Lithuania) · 2023Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is a major cause of disability and death worldwide. Prevention aimed at risk factors of stroke is the most effective strategy to curb the stroke pandemic. Hypertension is one of the most important risk factors for stroke. Despite the substantial evidence of the benefits of lowering blood pressure, conventional treatment does not normalize the burden of major cardiovascular events in patients with hypertension. Fully understanding the factors involved in the hypertension-induced stroke helps to develop new strategies for stroke prevention. Antihypertensive therapies selected should have positive blood pressure-independent effects on stroke risk. This review summarizes the factors involved in the hypertension-induced stroke, such as oxidative stress, inflammation, and arterial baroreflex dysfunction, and potential strategies for its prevention, therefore, provides clues for clinicians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.