ReviewCNS neuroscience & therapeutics2011
The genetics of white matter lesions.
Review in CNS neuroscience & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Candidate-gene analysis of white matter hyperintensities on neuroimaging.Journal of neurology, neurosurgery, and psychiatry · 2016Pooled it
- Cognitive dysfunction and depression in Fabry disease: a systematic review.Journal of inherited metabolic disease · 2014Pooled it
- White matter lesions contribute to motor and non-motor disorders in Parkinson's disease: a critical review.GeroScience · 2025Review
- CADASIL: A NOTCH3-associated cerebral small vessel disease.Journal of advanced research · 2024Review
- Genetic and Environmental Effects on the Development of White Matter Hyperintensities in a Middle Age Twin Population.Medicina (Kaunas, Lithuania) · 2022Article
- Neuroimaging Pearls from the MDS Congress Video Challenge. Part 1: Genetic Disorders.Movement disorders clinical practice · 2022Review
- Article
- Vascular depression for radiology: A review of the construct, methodology, and diagnosis.World journal of radiology · 2020Review
- The Associations ofFrontiers in genetics · 2019Article
- Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients: A cross-sectional study.Medicine · 2017Observational
- Analysis of genetic polymorphisms associated with leukoaraiosis in the southern Chinese population: A case-control study.Medicine · 2016Article
- Considerations for the Optimization of Induced White Matter Injury Preclinical Models.Frontiers in neurology · 2015Review
- The single nucleotide polymorphism rs2208454 confers an increased risk for ischemic stroke: a case-control study.CNS neuroscience & therapeutics · 2014Article
- Associations of white matter integrity and cortical thickness in patients with schizophrenia and healthy controls.Schizophrenia bulletin · 2014Article
- Associations between T1 white matter lesion volume and regional white matter microstructure in aging.Human brain mapping · 2014Article
- Article
- Impairments in Episodic-Autobiographical Memory and Emotional and Social Information Processing in CADASIL during Mid-Adulthood.Frontiers in behavioral neuroscience · 2014Article
- Clinical neurogenetics: stroke.Neurologic clinics · 2013Review
- Hemoglobin is associated with periventricular but not deep white matter hyperintensities in lacunar ischemic stroke.CNS neuroscience & therapeutics · 2013Article
- Multifocal white matter lesions associated with the D313Y mutation of the α-galactosidase A gene.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter lesions (WMLs), commonly seen as hyperintensities on T2-weighted MRI scans of healthy elderly individuals, are considered to be related to small vessel disease in the brain, and are often associated with subtle cognitive and functional impairments. WMLs also show a strong correlation with a wide range of neurodegenerative and neuropsychiatric disorders. Although a number of vascular risk factors for WMLs have been identified, genetic factors are also important with twin and family studies reporting high heritability. Mutations in several genes have been described that lead to monogenic disorders manifesting WMLs, such as Fabry disease and CADASIL. Because most individuals with WMLs do not have Mendelian disorders, most of the focus has been on single nucleotide polymorphisms as genetic risk markers for WMLs, either directly or through their interactions with other genes or medical risk factors. Candidate genes examined to date include those involved in cholesterol regulation and atherosclerosis, hypertension, neuronal repair, homocysteine levels, and oxidative stress pathways. In addition, although there have been a few genome-wide linkage studies, only one genome-wide association study has been performed. The majority of the genetic findings need independent replication, and studies need to be extended to other candidate genes. Collaborative efforts to examine genome-wide associations in large samples of both sexes of a broad age range using longitudinal studies are necessary. The identification of individuals genetically at risk of developing white matter lesions will have important implications for recognizing the etiology of WMLs and thereby developing clinical intervention strategies for their prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.