ArticleCNS neuroscience & therapeutics2011
Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats.
Article in CNS neuroscience & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis.Scientific reports · 2016Pooled it
- Effects of electroacupuncture on the functionality of NG2-expressing cells in perilesional brain tissue of mice following ischemic stroke.Neural regeneration research · 2022Article
- Corrigendum.CNS neuroscience & therapeutics · 2020Article
- Article
- The effect of age-related risk factors and comorbidities on white matter injury and repair after ischemic stroke.Neurobiology of disease · 2019Review
- Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion: inconclusive results.BMC neuroscience · 2018Article
- Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages.Frontiers in cellular neuroscience · 2018Article
- Article
- Subcortical ischemic vascular disease: Roles of oligodendrocyte function in experimental models of subcortical white-matter injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Review
- The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia.Current topics in medicinal chemistry · 2015Review
- ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia.Autophagy · 2014Article
- Extracellular visfatin has nicotinamide phosphoribosyltransferase enzymatic activity and is neuroprotective against ischemic injury.CNS neuroscience & therapeutics · 2014Article
- Involvement of arterial baroreflex in the protective effect of dietary restriction against stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Hepatocyte growth factor inhibits TGF-β1-induced myofibroblast differentiation in tendon fibroblasts: role of AMPK signaling pathway.The journal of physiological sciences : JPS · 2013Article
- ATP13A2 knockout does not affect the infarct size in mice with acute ischemic stroke.CNS neuroscience & therapeutics · 2012Article
- E-selectin deficiency attenuates brain ischemia in mice.CNS neuroscience & therapeutics · 2012Article
- Involvement of acetylcholine-α7nAChR in the protective effects of arterial baroreflex against ischemic stroke.CNS neuroscience & therapeutics · 2012Article
- The outcomes of stroke induced by middle cerebral artery occlusion in different strains of mice.CNS neuroscience & therapeutics · 2012Article
- Celecoxib inhibits growth of human autosomal dominant polycystic kidney cyst-lining epithelial cells through the VEGF/Raf/MAPK/ERK signaling pathway.Molecular biology reports · 2012Article
- Protection of different components of Danshen in cerebral infarction in mice.CNS neuroscience & therapeutics · 2012Article
Corrections and comments
- Erratum issuedCorrigendum.2020
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe purpose of this study is to investigate whether the NG2(+) cells, a class of oligodendrocyte progenitor cells, is involved in the pathophysiology of stroke in stroke-prone spontaneously hypertensive rat (SHR-SP).
methodsSHR-SP, SHR, Wistar-Kyoto rats (WKY), and C57BJ/6 mice were used. Immunohistochemistry was conducted to evaluate the number of NG2(+) cells in frozen brain sections. Demyelination was evaluated by Sudan black staining and serum level of myelin basic protein. Middle cerebral artery occlusion (MCAO) was performed to prepare experimental stroke model.
resultsThe number of NG2(+) cells was significantly decreased in infarct core and increased in penumbra in WKY rats after MCAO. In brain sections of 6-month-old SHR-SP, the number of NG2(+) cells was significantly (P < 0.01) less than that in age-matched SHR and WKY rats. However, this phenomenon was not observed in 3-month-old rats. Demyelination was found in 6-month-old SHR-SP but not in 3-month-old SHR-SP. Pharmacological treatment of cuprizone in mice induced demyelination and enlargement of cerebral infarction after MCAO.
conclusionThe decline of NG2(+) cells may cause demyelination and contribute to the susceptibility of SHR-SP to ischemic brain injury.
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