ArticleAnnals of the New York Academy of Sciences2011
Pharmacological tests of hypotheses for acquired pendular nystagmus.
Article in Annals of the New York Academy of Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Acetyl-DL-leucine in combination with memantine improves acquired pendular nystagmus caused by multiple sclerosis: a case report.Journal of neurology · 2023Article
- A 6-month trial of memantine for nystagmus and associated phenomena in oculopalatal tremor.Frontiers in neurology · 2022Article
- Oncologic causes of oculopalatal tremors: neurophysiology and treatment.Acta neurologica Belgica · 2021Review
- Hyperventilation Increases the Randomness of Ocular Palatal Tremor Waveforms.Cerebellum (London, England) · 2021Article
- Lessons learned from the syndrome of oculopalatal tremor.Journal of computational neuroscience · 2021Review
- Gabapentin and memantine increases randomness of oscillatory waveform in ocular palatal tremor.Journal of computational neuroscience · 2021Article
- Palatal Tremor - Pathophysiology, Clinical Features, Investigations, Management and Future Challenges.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Review
- The Comprehensive Management of Cerebellar Ataxia in Adults.Current treatment options in neurology · 2019Review
- Eye Movement Research in the Twenty-First Century-a Window to the Brain, Mind, and More.Cerebellum (London, England) · 2018Article
- Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment.Frontiers in neurology · 2018Review
- Acquired pendular nystagmus.Journal of the neurological sciences · 2017Review
- Hypertrophic Olivary Degeneration and Palatal or Oculopalatal Tremor.Frontiers in neurology · 2017Review
- Abnormal head oscillations in neuro-ophthalmology and neuro-otology.Current opinion in neurology · 2016Review
- Ocular palatal tremor plus dystonia - new syndromic association.Movement disorders clinical practice · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Acquired pendular nystagmus (APN) occurs with multiple sclerosis (MS) and oculopalatal tremor (OPT); distinct features of the nystagmus have led to the development of separate models for their pathogenesis. APN in MS has been attributed to instability in the neural integrator, which normally ensures steady gaze. APN in OPT may result from electrotonic coupling between neurons in the hypertrophied inferior olivary nucleus, which induces maladaptive learning in cerebellar cortex. We tested these two hypotheses by analyzing the effects of gabapentin, memantine, and baclofen on both forms of nystagmus. No drug changed the dominant frequency of either form of APN, but the variability of frequency was affected with gabapentin and memantine in patients with OPT. The amplitude of APN in both MS and OPT was reduced with gabapentin and memantine, but not baclofen. Analyzing the effects of drug therapies on ocular oscillations provides a novel approach to test models of nystagmus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.