ArticleJournal of biomedical optics2011
Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques.
Article in Journal of biomedical optics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery.JACC. Basic to translational science · 2021Article
- Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions.Journal of biophotonics · 2021Review
- Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging.Sensors (Basel, Switzerland) · 2021Review
- Current Advances in the Diagnostic Imaging of Atherosclerosis: Insights into the Pathophysiology of Vulnerable Plaque.International journal of molecular sciences · 2020Review
- Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging.Scientific reports · 2018Article
- Scanning Acoustic Microscopy and Time-Resolved Fluorescence Spectroscopy for Characterization of Atherosclerotic Plaques.Scientific reports · 2018Article
- Label-free assessment of carotid artery biochemical composition using fiber-based fluorescence lifetime imaging.Biomedical optics express · 2018Article
- Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography.Biomedical optics express · 2018Article
- Two-photon autofluorescence lifetime imaging of human skin papillary dermis in vivo: assessment of blood capillaries and structural proteins localization.Scientific reports · 2017Article
- Fluorescent lifetime imaging microscopy using Europium complexes improves atherosclerotic plaques discrimination.The international journal of cardiovascular imaging · 2016Article
- Fluorescence Lifetime Imaging Combined with Conventional Intravascular Ultrasound for Enhanced Assessment of Atherosclerotic Plaques: an Ex Vivo Study in Human Coronary Arteries.Journal of cardiovascular translational research · 2015Article
- Macrophages and intravascular OCT bright spots: a quantitative study.JACC. Cardiovascular imaging · 2015Article
- Design and evaluation of a device for fast multispectral time-resolved fluorescence spectroscopy and imaging.The Review of scientific instruments · 2014Article
- Endoscopic fluorescence lifetime imaging for in vivo intraoperative diagnosis of oral carcinoma.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2013Article
- Pulse shape discrimination and classification methods for continuous depth of interaction encoding PET detectors.Physics in medicine and biology · 2012Article
- Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound.Journal of biomedical optics · 2012Article
- A fluorescence lifetime imaging classification method to investigate the collagen to lipid ratio in fibrous caps of atherosclerotic plaque.Lasers in surgery and medicine · 2012Article
- Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis.Biomedical optics express · 2012Article
- Biochemical characterization of atherosclerotic plaques by endogenous multispectral fluorescence lifetime imaging microscopy.Atherosclerosis · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
This study investigates the ability of a flexible fiberoptic-based fluorescence lifetime imaging microscopy (FLIM) technique to resolve biochemical features in plaque fibrotic cap associated with plaque instability and based solely on fluorescence decay characteristics. Autofluorescence of atherosclerotic human aorta (11 autopsy samples) was measured at 48 locations through two filters, F377: 377∕50 and F460: 460∕60 nm (center wavelength∕bandwidth). The fluorescence decay dynamic was described by average lifetime (τ) and four Laguerre coefficients (LECs) retrieved through a Laguerre deconvolution technique. FLIM-derived parameters discriminated between four groups [elastin-rich (ER), elastin and macrophage-rich (E+M), collagen-rich (CR), and lipid-rich (LR)]. For example, τ(F377) discriminated ER from CR (R = 0.84); τ(F460) discriminated E+M from CR and ER (R = 0.60 and 0.54, respectively); LEC-1(F377) discriminated CR from LR and E+M (R = 0.69 and 0.77, respectively); P < 0.05 for all correlations. Linear discriminant analysis was used to classify this data set with specificity >87% (all cases) and sensitivity as high as 86%. Current results demonstrate for the first time that clinically relevant features (e.g., ratios of lipid versus collagen versus elastin) can be evaluated with a flexible-fiber based FLIM technique without the need for fluorescence intensity information or contrast agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.