Evidence map›Paper›PMID 21950736›Full record

Trial reportBritish journal of pharmacology2012

Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation.

S Bodenmann, C Hohoff, C Freitag, J Deckert, J V Rétey, V Bachmann, H-P Landolt

Open access · greenAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Caffeine intake and anxiety: a meta-analysis.Frontiers in psychology · 2024
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Acute effects of energy drinks in medical students.European journal of nutrition · 2017
    Trial
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. International society of sports nutrition position stand: caffeine and exercise performance.Journal of the International Society of Sports Nutrition · 2021
    Review
  16. ADORA2A variation and adenosine ATranslational psychiatry · 2020
    Article
  17. Article
  18. Article
  19. Sleep in the United States Military.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

S BodenmannInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, SwitzerlandDepartment of Psychiatry, University of Münster, Münster, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann-Wolfgang Goethe University, Frankfurt am Main, GermanyDepartment of Psychiatry, University of Würzburg, Würzburg, GermanyZürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
C HohoffInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, SwitzerlandDepartment of Psychiatry, University of Münster, Münster, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann-Wolfgang Goethe University, Frankfurt am Main, GermanyDepartment of Psychiatry, University of Würzburg, Würzburg, GermanyZürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
C FreitagInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, SwitzerlandDepartment of Psychiatry, University of Münster, Münster, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann-Wolfgang Goethe University, Frankfurt am Main, GermanyDepartment of Psychiatry, University of Würzburg, Würzburg, GermanyZürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
J DeckertInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, SwitzerlandDepartment of Psychiatry, University of Münster, Münster, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann-Wolfgang Goethe University, Frankfurt am Main, GermanyDepartment of Psychiatry, University of Würzburg, Würzburg, GermanyZürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
J V RéteyInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, SwitzerlandDepartment of Psychiatry, University of Münster, Münster, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann-Wolfgang Goethe University, Frankfurt am Main, GermanyDepartment of Psychiatry, University of Würzburg, Würzburg, GermanyZürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
V BachmannInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, SwitzerlandDepartment of Psychiatry, University of Münster, Münster, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann-Wolfgang Goethe University, Frankfurt am Main, GermanyDepartment of Psychiatry, University of Würzburg, Würzburg, GermanyZürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
H-P LandoltInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, SwitzerlandDepartment of Psychiatry, University of Münster, Münster, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann-Wolfgang Goethe University, Frankfurt am Main, GermanyDepartment of Psychiatry, University of Würzburg, Würzburg, GermanyZürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
University of Zurich · CHUniversity of Münster · DEGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeProlonged wakefulness impairs sustained vigilant attention, measured with the psychomotor vigilance task (PVT), and induces a compensatory increase in sleep intensity in recovery sleep, quantified by slow-wave activity (SWA) in the sleep electroencephalogram (EEG). These effects of sleep deprivation are counteracted by the adenosine receptor antagonist caffeine, implying involvement of the adenosine neuromodulator/receptor system. To examine a role for adenosine A(2A) receptors, we investigated whether variation of the A(2A) receptor gene (ADORA2A) modified effects of caffeine on PVT and SWA after sleep deprivation. EXPERIMENTAL APPROACH: A haplotype analysis of eight single-nucleotide polymorphisms of ADORA2A was performed in 82 volunteers. In 45 young men carrying five different allele combinations, we investigated the effects of prolonged waking and 2 × 200 mg caffeine or 2 × 100 mg modafinil on psychomotor vigilance, sleepiness, and the waking and sleep EEG. KEY

resultsThroughout extended wakefulness, the carriers of haplotype HT4 performed faster on the PVT than carriers of non-HT4 haplotype alleles. In haplotype HT4, caffeine failed to counteract the waking-induced impairment of PVT performance and the rebound of SWA in recovery sleep. However, caffeine was effective in non-HT4 allele carriers, and modafinil reduced the consequences of prolonged waking, independently of ADORA2A haplotype. CONCLUSIONS AND IMPLICATIONS: Common genetic variation of ADORA2A is an important determinant of psychomotor vigilance in rested and sleep-deprived state. It also modulates individual responses to caffeine after sleep deprivation. These findings demonstrate a role for adenosine A(2A) receptors in the effects of prolonged wakefulness on vigilant attention and the sleep EEG.

Indexed as

AdultAgedAttentionBenzhydryl CompoundsCaffeineCentral Nervous System StimulantsCross-Over StudiesDouble-Blind MethodElectroencephalographyFemaleHumansMaleMiddle AgedModafinilPolymorphism, Single NucleotidePsychomotor PerformanceBenzhydryl CompoundsCaffeineCentral Nervous System StimulantsModafinilPurinergic P1 Receptor AntagonistsReceptor, Adenosine A2A

Identifiers

PMID21950736
PMCPMC3372839
OpenAlexW2096079323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.