ArticleCurrent eye research2011
Single cell imaging of the chick retina with adaptive optics.
Article in Current eye research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response.Cells · 2022Article
- Article
- Arrangement of the photoreceptor mosaic in a diabetic rat model imaged with multiphoton microscopy.Biomedical optics express · 2020Article
- Noninvasive Imaging and Correlative Histology of Cone Photoreceptor Structure in the Pig Retina.Translational vision science & technology · 2019Article
- The chick eye in vision research: An excellent model for the study of ocular disease.Progress in retinal and eye research · 2017Review
- Mechanisms of Photoreceptor Patterning in Vertebrates and Invertebrates.Trends in genetics : TIG · 2016Review
- Directionality of individual cone photoreceptors in the parafoveal region.Vision research · 2015Article
- Measurement of the photoreceptor pointing in the living chick eye.Vision research · 2015Article
- James Webb Space Telescope segment phasing using differential optical transfer functions.Journal of astronomical telescopes, instruments, and systems · 2015Article
- Retinal imaging using adaptive optics technology.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2014Article
- Retinal cell imaging in myopic chickens using adaptive optics multiphoton microscopy.Biomedical optics express · 2014Article
- A chick model of retinal detachment: cone rich and novel.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe chick eye is extensively used as a model in the study of myopia and its progression; however, analysis of the photoreceptor mosaic has required the use of excised retina due to the uncorrected optical aberrations in the lens and cornea. This study implemented high resolution adaptive optics (AO) retinal imaging to visualize the chick cone mosaic in vivo.
methodsThe New England College of Optometry (NECO) AO fundus camera was modified to allow high resolution in vivo imaging on two 6-week-old White Leghorn chicks (Gallus gallus domesticus)-labeled chick A and chick B. Multiple, adjacent images, each with a 2.5(o) field of view, were taken and subsequently montaged together. This process was repeated at varying retinal locations measured from the tip of the pecten. Automated software was used to determine the cone spacing and density at each location. Voronoi analysis was applied to determine the packing arrangement of the cones.
resultsIn both chicks, cone photoreceptors were clearly visible at all retinal locations imaged. Cone densities measured at 36(o) nasal-12(o) superior retina from the pecten tip for chick A and 40(o) nasal-12(o) superior retina for chick B were 21,714 ± 543 and 26,105 ± 653 cones/mm(2) respectively. For chick B, a further 11 locations immediately surrounding the pecten were imaged, with cone densities ranging from 20,980 ± 524 to 25,148 ± 629 cones/mm(2).
conclusionIn vivo analysis of the cone density and its packing characteristics are now possible in the chick eye through AO imaging, which has important implications for future studies of myopia and ocular disease research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.