ArticleThe Journal of clinical investigation1990
Epithelial basement membrane of mouse jejunum. Evidence for laminin turnover along the entire crypt-villus axis.
Article in The Journal of clinical investigation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- Zebrafish knock-in lines enabling live visualization of extracellular matrix dynamics during development and regeneration.Development (Cambridge, England) · 2026Article
- Ageing impacts extracellular matrix turnover and remodelling in the kidney.Matrix biology plus · 2026Article
- Accelerated basement membrane remodeling and serum matrix fragments as biomarkers of fibrosis in Alport syndrome.Cell reports · 2026Article
- Live visualization of extracellular matrix dynamics during development and regeneration in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome.The Journal of cell biology · 2025Article
- Article
- Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance.Fluids and barriers of the CNS · 2024Article
- Basement membrane dynamics and mechanics in tissue morphogenesis.Biology open · 2023Review
- Dynamic movement and turnover of extracellular matrices during tissue development and maintenance.Fly · 2022Review
- Matritecture: Mapping the extracellular matrix architecture during health and disease.Matrix biology plus · 2022Article
- To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease.Open biology · 2021Review
- Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding.Developmental cell · 2020Article
- Role of Hypohalous Acids in Basement Membrane Homeostasis.Antioxidants & redox signaling · 2017Review
- Article
- Assembly, heterogeneity, and breaching of the basement membranes.Cell adhesion & migration · 2014Review
- Regulation of the basement membrane by epithelia generated forces.Physical biology · 2012Article
- Glutamine synthetase and glucose-6-phosphate isomerase are adhesive moonlighting proteins of Lactobacillus crispatus released by epithelial cathelicidin LL-37.Journal of bacteriology · 2012Article
- Substrate viscosity enhances correlation in epithelial sheet movement.Biophysical journal · 2011Article
- Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans.Nature cell biology · 2011Article
- Computational model of cell positioning: directed and collective migration in the intestinal crypt epithelium.Journal of the Royal Society, Interface · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Little is known regarding turnover of the epithelial basement membrane in adult small intestine. Are components degraded and inserted along the length of the crypt-villus axis or selectively in the crypt region with subsequent migration of basement membrane from crypt to villus tip in concert with epithelium? We injected affinity-purified sheep anti-laminin IgG or sheep anti-laminin IgG complexed to horseradish peroxidase (HRP) into mice to label basement membrane laminin in vivo. Fluorescence microscopy revealed linear fluorescence along the length of the jejunal epithelial basement membrane 1 d after anti-laminin IgG injection. By 1 wk, small nonfluorescent domains were interposed between larger fluorescent domains. Over the next 5 wk the lengths of nonfluorescent domains increased progressively whereas those of fluorescent domains decreased. Additionally, electron microscopy revealed HRP reaction product along the length of the epithelial basement membrane after 1 d whereas unlabeled or lightly labeled domains that increased in length with time were observed interposed between heavily labeled domains by 2 and 4 wk along the entire crypt-villus axis. We conclude that laminin turnover occurs focally in the epithelial basement membrane of mouse jejunum along the crypt-villus axis over a period of weeks and that this basement membrane does not comigrate in concert with its overlying epithelium.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.