ArticlePhotochemistry and photobiology
Optimal photosensitizers for photodynamic therapy of infections should kill bacteria but spare neutrophils.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 77 citations in OpenAlex.
- On the Photo-Eradication of Methicillin-ResistantInternational journal of molecular sciences · 2023Article
- Application of Reactive Oxygen Species in Dental Treatment.Journal of personalized medicine · 2022Review
- Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.Lasers in medical science · 2021Article
- Article
- Potassium iodide enhances the photobactericidal effect of methylene blue on Enterococcus faecalis as planktonic cells and as biofilm infection in teeth.Journal of photochemistry and photobiology. B, Biology · 2020Article
- Photodynamic enhancement of the activity of antibiotics used in urinary tract infections.Lasers in medical science · 2019Article
- Uptake and release of photosensitizers in a hydrogel for applications in photodynamic therapy: the impact of structural parameters on intrapolymer transport dynamics.RSC advances · 2018Article
- Bactericide effect of methylene blue associated with low-level laser therapy in Escherichia coli bacteria isolated from pressure ulcers.Lasers in medical science · 2018Article
- Antimicrobial Photodynamic Inactivation Mediated by Rose Bengal and Erythrosine Is Effective in the Control of Food-Related Bacteria in Planktonic and Biofilm States.Molecules (Basel, Switzerland) · 2018Article
- Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei.Lasers in medical science · 2018Article
- Antimicrobial photodynamic therapy-a promising treatment for prosthetic joint infections.Lasers in medical science · 2018Article
- Chlorin e6 mediated photodynamic inactivation for multidrug resistant Pseudomonas aeruginosa keratitis in mice in vivo.Scientific reports · 2017Article
- Bactericidal Effect of Photodynamic Therapy, Alone or in Combination with Mupirocin or Linezolid, onFrontiers in microbiology · 2017Article
- Comparative Study on the Efficiency of the Photodynamic Inactivation of Candida albicans Using CdTe Quantum Dots, Zn(II) Porphyrin and Their Conjugates as Photosensitizers.Molecules (Basel, Switzerland) · 2015Article
- Novel Broad-Spectrum Antimicrobial Photoinactivation of In Situ Oral Biofilms by Visible Light plus Water-Filtered Infrared A.Applied and environmental microbiology · 2014Article
- Photodynamic inactivation of Candida albicans mediated by a low density of light energy.Lasers in medical science · 2014Article
- Photoinduced membrane damage of E. coli and S. aureus by the photosensitizer-antimicrobial peptide conjugate eosin-(KLAKLAK)2.PloS one · 2014Article
- Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond.Current opinion in pharmacology · 2013Review
- Dye Sensitizers for Photodynamic Therapy.Materials (Basel, Switzerland) · 2013Review
- BODIPY dyes in photodynamic therapy.Chemical Society reviews · 2013Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Photodynamic therapy (PDT) for localized microbial infections exerts its therapeutic effect both by direct bacterial killing and also by the bactericidal effects of host neutrophils stimulated by PDT. Therefore, PDT-induced damage to neutrophils must be minimized, while direct photoinactivation of bacteria is maintained to maximize the therapeutic efficacy of antimicrobial PDT in vivo. However, there has been no study in which the cytocidal effect of PDT on neutrophils was investigated. In this study, the cytocidal effects of PDT on neutrophils were evaluated using different antimicrobial photosensitizers to find suitable candidate photosensitizers for antimicrobial PDT. PDT on murine peripheral-blood neutrophils was performed in vitro using each photosensitizer at a concentration that exerted a maximum bactericidal effect on methicillin-resistant Staphylococcus aureus, and morphological alteration and viability of neutrophils were studied. Most neutrophils were viable (>80%) after PDT using toluidine blue-O (TB) or methylene blue (MB), while neutrophils showed morphological change and their viabilities were decreased (<70%) after PDT using other photosensitizers (erythrosine B, rose bengal, crystal violet, Photofrin, new methylene blue and Laserphyrin). These results suggest that PDT using TB or MB can preserve host neutrophils while exerting a significant therapeutic effect on in vivo localized microbial infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.