ArticlePLoS neglected tropical diseases2011
Epidemiologic relationship between Toscana virus infection and Leishmania infantum due to common exposure to Phlebotomus perniciosus sandfly vector.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Negative interactions between Toscana virus and Leishmania infantum limit coinfection in sand flies.Parasites & vectors · 2026Article
- Two strains of Toscana virus show different virulence and replication capacity in mice and cell culture models.Virulence · 2025Article
- Seroprevalence of Toscana virus in blood donors in mainland Portugal.Parasites & vectors · 2025Article
- Serosurvey of canine leishmaniasis in five departments near an identified human clinical case in Marseille (France).One health (Amsterdam, Netherlands) · 2024Article
- Co-Circulation ofTropical medicine and infectious disease · 2023Article
- The estimated distribution of autochthonous leishmaniasis by Leishmania infantum in Europe in 2005-2020.PLoS neglected tropical diseases · 2023Review
- The Role of theViruses · 2023Article
- Exposure to Phlebotomus perniciosus sandfly vectors is positively associated with Toscana virus and Leishmania infantum infection in human blood donors in Murcia Region, southeast Spain.Transboundary and emerging diseases · 2022Article
- Sandfly Blood-Feeding Habits and Competence in Transmitting Ntepes Virus, a Recently Discovered Member of the GenusBioMed research international · 2022Article
- Co-Circulation of Phleboviruses andViruses · 2021Article
- Altitude and hillside orientation shapes the population structure of the Leishmania infantum vector Phlebotomus ariasi.Scientific reports · 2020Article
- Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal.Microorganisms · 2019Article
- The small non-coding RNA response to virus infection in the Leishmania vector Lutzomyia longipalpis.PLoS neglected tropical diseases · 2018Article
- Phlebotomine sand flies (Diptera: Psychodidae) in the Greek Aegean Islands: ecological approaches.Parasites & vectors · 2018Article
- Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Serological association between Leishmania infantum and sand fly fever Sicilian (but not Toscana) virus in sheltered dogs from southern Portugal.Parasites & vectors · 2017Article
- Canine Infections and Partial S Segment Sequence Analysis of Toscana Virus in Turkey.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2016Article
- Phleboviruses detection in Phlebotomus perniciosus from a human leishmaniasis focus in South-West Madrid region, Spain.Parasites & vectors · 2016Article
- Ecology and spatiotemporal dynamics of sandflies in the Mediterranean Languedoc region (Roquedur area, Gard, France).Parasites & vectors · 2015Article
- Potential animal reservoirs of Toscana virus and coinfections with Leishmania infantum in Turkey.The American journal of tropical medicine and hygiene · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sand flies are recognised vectors of parasites in the genus Leishmania and a number of arthropod-borne viruses, in particular viruses within the genus Phlebovirus, family Bunyaviridae. In southern France, Toscana phlebovirus (TOSV) is recognized as a prominent cause of summer meningitis. Since Leishmania and TOSV have a common vector (Phlebotomus perniciosus), an epidemiologic link has been assumed for a long time. However, there is no scientific evidence of such a link between human leishmaniosis and phleboviral infections. To identify a possible link, we investigated the presence and distribution of antibodies against these two microorganisms (i) in individuals and (ii) at a spatial level in the city of Marseille (south-eastern France). Five hundred sera were selected randomly in the biobank of the Department of Parasitology of the Public Hospitals of Marseille. All sera were previously tested for IgG against Leishmania by Western Blotting, and TOSV IgG were detected by indirect immunofluorescence. The seropositivity rates were 21.4% for TOSV and 28% for Leishmania. Statistical analysis demonstrated that seropositivity for one pathogen was significantly associated with seropositivity to the other pathogen. This result provided the first robust evidence for the existence of an epidemiological relationship between Leishmania infantum and TOSV. Addresses of tested patients were geolocalized and integrated into Geographical Information System software, in order to test spatial relationship between the two pathogens. Spatial analysis did not allow to identify (i) specific patterns for the spatial distribution of positive serological results for TOSV or Leishmania, and (ii) a spatial relationship between Leishmania and TOSV positive serological results. This may reflect the fact that the sample studied was not powerful enough to demonstrate either a spatial clustering or co-location, i.e. that the actual risk exposure area is smaller than the mean of distance between patients in our study (245 m).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.