ArticlePLoS neglected tropical diseases2011
Risk of Buruli ulcer and detection of Mycobacterium ulcerans in mosquitoes in southeastern Australia.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- A need for null models in understanding disease transmission: the example of Mycobacterium ulcerans (Buruli ulcer disease).FEMS microbiology reviews · 2022Pooled it
- Buruli ulcer.Nature reviews. Disease primers · 2025Review
- Spatiotemporal distribution ofEmerging microbes & infections · 2025Article
- Risk factors for Buruli ulcer disease in Ghana: A matched case-control study in four selected endemic districts of Eastern and Oti Regions.PLoS neglected tropical diseases · 2025Article
- The Role of Foxes in Transmitting Zoonotic Bacteria to Humans: A Scoping Review.Zoonoses and public health · 2025Article
- Buruli ulcer surveillance in south-eastern Australian possums: Infection status, lesion mapping and internal distribution of Mycobacterium ulcerans.PLoS neglected tropical diseases · 2024Article
- Mosquitoes as Vectors of Mycobacterium ulcerans Based on Analysis of Notifications of Alphavirus Infection and Buruli Ulcer, Victoria, Australia.Emerging infectious diseases · 2024Article
- Systematic review: Global host range, case fatality and detection rates ofJournal of clinical tuberculosis and other mycobacterial diseases · 2024Review
- Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia.Nature microbiology · 2024Article
- Review
- Mycobacterium ulcerans not detected by PCR on human skin in Buruli ulcer endemic areas of south eastern Australia.PLoS neglected tropical diseases · 2023Article
- Comprehensive Case-Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia.Emerging infectious diseases · 2023Article
- Statistical modeling based on structured surveys of Australian native possum excreta harboringeLife · 2023Article
- Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia.PloS one · 2022Article
- Linking theOne health (Amsterdam, Netherlands) · 2021Review
- Correlation between Buruli Ulcer Incidence and Vectorborne Diseases, Southeastern Australia, 2000-2020.Emerging infectious diseases · 2021Article
- Understanding the transmission of Mycobacterium ulcerans: A step towards controlling Buruli ulcer.PLoS neglected tropical diseases · 2021Review
- Community-based geographical distribution of Mycobacterium ulcerans VNTR-genotypes from the environment and humans in the Nyong valley, Cameroon.Tropical medicine and health · 2021Article
- Does skin surface temperature variation account for Buruli ulcer lesion distribution?PLoS neglected tropical diseases · 2020Observational
- Buruli ulcer: The Efficacy of Innate Immune Defense May Be a Key Determinant for the Outcome of Infection WithFrontiers in microbiology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBuruli ulcer (BU) is a destructive skin condition caused by infection with the environmental bacterium, Mycobacterium ulcerans. The mode of transmission of M. ulcerans is not completely understood, but several studies have explored the role of biting insects. In this study, we tested for an association between the detection of M. ulcerans in mosquitoes and the risk of BU disease in humans in an endemic area of southeastern Australia. METHODOLOGY/PRINCIPAL
findingsAdult mosquitoes were trapped in seven towns on the Bellarine Peninsula in Victoria, Australia, from December 2004 to December 2009 and screened for M. ulcerans by real-time PCR. The number of laboratory-confirmed cases of BU in permanent residents of these towns diagnosed during the same period was tallied to determine the average cumulative incidence of BU in each location. Pearson's correlation coefficient (r) was calculated for the proportion of M. ulcerans-positive mosquitoes per town correlated with the incidence of BU per town. We found a strong dose-response relationship between the detection of M. ulcerans in mosquitoes and the risk of human disease (r, 0.99; 95% CI, 0.92-0.99; p < 0.001). CONCLUSIONS/SIGNIFICANCE: The results of this study strengthen the hypothesis that mosquitoes are involved in the transmission of M. ulcerans in southeastern Australia. This has implications for the development of intervention strategies to control and prevent BU.
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