ArticlePloS one2011
A membrane-bound vertebrate globin.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Insights into the function of cytoglobin.Biochemical Society transactions · 2023Review
- Whole-Genome Duplications and the Diversification of the Globin-X Genes of Vertebrates.Genome biology and evolution · 2021Article
- Co-Regulated Genes and Gene Clusters.Genes · 2021Review
- Structural modeling of a novel membrane-bound globin-coupled sensor inComputational and structural biotechnology journal · 2021Article
- Globins in the marine annelid Platynereis dumerilii shed new light on hemoglobin evolution in bilaterians.BMC evolutionary biology · 2020Article
- Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport.Redox biology · 2020Review
- The Globin Gene Family in Arthropods: Evolution and Functional Diversity.Frontiers in genetics · 2020Article
- Myoglobin as a versatile peroxidase: Implications for a more important role for vertebrate striated muscle in antioxidant defense.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2019Article
- The Zebrafish CytochromeBiochemistry · 2019Article
- Globin E is a myoglobin-related, respiratory protein highly expressed in lungfish oocytes.Scientific reports · 2019Article
- Evidence for a Large Expansion and Subfunctionalization of Globin Genes in Sea Anemones.Genome biology and evolution · 2018Article
- Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.Chemical reviews · 2018Article
- Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates.Genome biology and evolution · 2018Article
- Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences.Biochimica et biophysica acta · 2016Article
- Globin-based redox signaling.Worm · 2016Article
- Ancient Duplications and Expression Divergence in the Globin Gene Superfamily of Vertebrates: Insights from the Elephant Shark Genome and Transcriptome.Molecular biology and evolution · 2015Article
- The Full Globin Repertoire of Turtles Provides Insights into Vertebrate Globin Evolution and Functions.Genome biology and evolution · 2015Article
- More than hemoglobin - the unexpected diversity of globins in vertebrate red blood cells.Physiological reports · 2015Article
- Phylogeny of Echinoderm Hemoglobins.PloS one · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The family of vertebrate globins includes hemoglobin, myoglobin, and other O(2)-binding proteins of yet unclear functions. Among these, globin X is restricted to fish and amphibians. Zebrafish (Danio rerio) globin X is expressed at low levels in neurons of the central nervous system and appears to be associated with the sensory system. The protein harbors a unique N-terminal extension with putative N-myristoylation and S-palmitoylation sites, suggesting membrane-association. Intracellular localization and transport of globin X was studied in 3T3 cells employing green fluorescence protein fusion constructs. Both myristoylation and palmitoylation sites are required for correct targeting and membrane localization of globin X. To the best of our knowledge, this is the first time that a vertebrate globin has been identified as component of the cell membrane. Globin X has a hexacoordinate binding scheme and displays cooperative O(2) binding with a variable affinity (P(50)∼1.3-12.5 torr), depending on buffer conditions. A respiratory function of globin X is unlikely, but analogous to some prokaryotic membrane-globins it may either protect the lipids in cell membrane from oxidation or may act as a redox-sensing or signaling protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.