ArticlePloS one2011
Reduced transmissibility of East African Indian strains of Mycobacterium tuberculosis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis.BMC medicine · 2018Pooled it
- A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesPooled it
- Importance of cough and M. tuberculosis strain type as risks for increased transmission within households.PloS one · 2014Trial
- Changes in the incidence and profile of pediatric tuberculosis in France from 2014 to 2023: impact of COVID-19 non-pharmaceutical interventions implementation and lifting.European journal of pediatrics · 2026Article
- Genetic Diversity and Molecular Epidemiology ofPathogens (Basel, Switzerland) · 2026Article
- Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.PLoS pathogens · 2023Article
- Whole genome sequencing for tuberculosis in Victoria, Australia: A genomic implementation study from 2017 to 2020.The Lancet regional health. Western Pacific · 2022Article
- Transmission, distribution and drug resistance-conferring mutations of extensively drug-resistant tuberculosis in the Western Cape Province, South Africa.Microbial genomics · 2022Article
- Molecular Epidemiology and Genetic Diversity of Multidrug-Resistant Mycobacterium tuberculosis Isolates in Bangladesh.Microbiology spectrum · 2022Article
- Sub-Lineage Specific Phenolic Glycolipid Patterns in theFrontiers in microbiology · 2022Article
- Rv0180c contributes to Mycobacterium tuberculosis cell shape and to infectivity in mice and macrophages.PLoS pathogens · 2021Article
- Population structure, biogeography and transmissibility of Mycobacterium tuberculosis.Nature communications · 2021Article
- Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care.Diagnostics (Basel, Switzerland) · 2021Review
- Distribution and Clonality of drug-resistant tuberculosis in South Africa.BMC microbiology · 2021Article
- Genetic variability in multidrug-resistant Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in North India.BMC microbiology · 2021Article
- Comparative genomics shows differences in the electron transport and carbon metabolic pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension.Tuberculosis (Edinburgh, Scotland) · 2020Article
- Characterization of DNA methylation in MalawianPeerJ · 2020Article
- Review
- Transmission phenotype of Mycobacterium tuberculosis strains is mechanistically linked to induction of distinct pulmonary pathology.PLoS pathogens · 2019Article
- Genotypic diversity of Mycobacterium tuberculosis isolates from North-Central Indian population.Pathogens and global health · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundMycobacterium tuberculosis (MTB) has been classified into 4 main lineages. Some reports have associated certain lineages with particular clinical phenotypes, but there is still insufficient information regarding the clinical and epidemiologic implications of MTB lineage variation.
methodsUsing large sequence polymorphisms we classified MTB isolates from a population-based study in Montreal, Canada into the 4 major lineages, and identified the associated clinical and epidemiologic features. In addition, IS6110-RFLP and spoligotyping were used as indicators of recent TB transmission. The study population was divided into a derivation cohort, diagnosed between 2001 and 2007, and a separate validation cohort, diagnosed between 1996 and 2000.
resultsIn the derivation cohort, when compared to the other MTB lineages, the East African-Indian (EAI) lineage was associated with lower rates of TB transmission, as measured by: positive TST among close contacts of pulmonary TB cases (adjusted odds ratio 0.6: [95% confidence interval 0.4-0.9]), and clustered TB cases (0.3: [<0.001-0.6]). Severe forms of TB were also less likely among the EAI group (0.4: [<0.001-0.8]). There were no significant differences when comparing patients with the other MTB lineages. In the validation cohort, the EAI lineage was associated with lower rates of positive TST among contacts (0.5: [0.3-0.9]) and a trend towards less clustered TB cases (0.5: [0.1-1.8]) when compared to the other lineages. Disease severity among the different groups was not significantly different in the validation cohort.
conclusionsWe conclude that in Montreal, EAI strains were associated with reduced transmission compared to other MTB lineages.
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