ArticlePloS one2011
Long-distance signals are required for morphogenesis of the regenerating Xenopus tadpole tail, as shown by femtosecond-laser ablation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Tail and Spinal Cord Regeneration in Urodelean Amphibians.Life (Basel, Switzerland) · 2024Review
- A Novel Perspective on Neuronal Control of Anatomical Patterning, Remodeling, and Maintenance.International journal of molecular sciences · 2023Review
- Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook.Cold Spring Harbor perspectives in biology · 2022Review
- Preventing Ethanol-Induced Brain and Eye Morphology Defects Using Optogenetics.Bioelectricity · 2019Article
- Neural control of body-plan axis in regenerating planaria.PLoS computational biology · 2019Article
- Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb.Cell reports · 2018Article
- The bioelectric code: An ancient computational medium for dynamic control of growth and form.Bio Systems · 2018Review
- The brain is required for normal muscle and nerve patterning during early Xenopus development.Nature communications · 2017Article
- Vertically- and horizontally-transmitted memories - the fading boundaries between regeneration and inheritance in planaria.Biology open · 2016Review
- The cellular and molecular mechanisms of tissue repair and regeneration as revealed by studies inRegeneration (Oxford, England) · 2016Article
- Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form.Regeneration (Oxford, England) · 2016Article
- On Having No Head: Cognition throughout Biological Systems.Frontiers in psychology · 2016Review
- Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs.Integrative biology : quantitative biosciences from nano to macro · 2015Review
- Gap Junctional Blockade Stochastically Induces Different Species-Specific Head Anatomies in Genetically Wild-Type Girardia dorotocephala Flatworms.International journal of molecular sciences · 2015Article
- A linear-encoding model explains the variability of the target morphology in regeneration.Journal of the Royal Society, Interface · 2014Review
- Transgenic analysis of signaling pathways required for Xenopus tadpole spinal cord and muscle regeneration.Anatomical record (Hoboken, N.J. : 2007) · 2012Article
- Transducing bioelectric signals into epigenetic pathways during tadpole tail regeneration.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
- Morphogenetic fields in embryogenesis, regeneration, and cancer: non-local control of complex patterning.Bio Systems · 2012Review
- Amphioxus makes the cut-Again.Communicative & integrative biology · 2012Article
- Normalized shape and location of perturbed craniofacial structures in the Xenopus tadpole reveal an innate ability to achieve correct morphology.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundWith the goal of learning to induce regeneration in human beings as a treatment for tissue loss, research is being conducted into the molecular and physiological details of the regeneration process. The tail of Xenopus laevis tadpoles has recently emerged as an important model for these studies; we explored the role of the spinal cord during tadpole tail regeneration. METHODS AND
resultsUsing ultrafast lasers to ablate cells, and Geometric Morphometrics to quantitatively analyze regenerate morphology, we explored the influence of different cell populations. For at least twenty-four hours after amputation (hpa), laser-induced damage to the dorsal midline affected the morphology of the regenerated tail; damage induced 48 hpa or later did not. Targeting different positions along the anterior-posterior (AP) axis caused different shape changes in the regenerate. Interestingly, damaging two positions affected regenerate morphology in a qualitatively different way than did damaging either position alone. Quantitative comparison of regenerate shapes provided strong evidence against a gradient and for the existence of position-specific morphogenetic information along the entire AP axis.
conclusionsWe infer that there is a conduit of morphology-influencing information that requires a continuous dorsal midline, particularly an undamaged spinal cord. Contrary to expectation, this information is not in a gradient and it is not localized to the regeneration bud. We present a model of morphogenetic information flow from tissue undamaged by amputation and conclude that studies of information coming from far outside the amputation plane and regeneration bud will be critical for understanding regeneration and for translating fundamental understanding into biomedical approaches.
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