ArticlePloS one2011
IgE recognition patterns of profilin, PR-10, and tropomyosin panallergens tested in 3,113 allergic patients by allergen microarray-based technology.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 47 citations in OpenAlex.
- Revisiting Fruit Allergy: Prevalence across the Globe, Diagnosis, and Current Management.Foods (Basel, Switzerland) · 2023Review
- Sensitization patterns of plant panallergens in Georgian allergic population from the molecular perspective.Postepy dermatologii i alergologii · 2023Article
- Not Just a Banana: The Extent of Fruit Cross-Reactivity and Reaction Severity in Adults with Banana Allergy.Foods (Basel, Switzerland) · 2023Article
- Food Allergens of Plant Origin.Foods (Basel, Switzerland) · 2023Review
- An Updated Overview of Almond Allergens.Nutrients · 2021Review
- Linking cross-reactivity clusters of food and respiratory allergens in PAMD@ to asthma and duration of allergy.The World Allergy Organization journal · 2020Article
- IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.The World Allergy Organization journal · 2020Article
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- The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study.BMC pulmonary medicine · 2018Observational
- Allergen Valency, Dose, and FcεRI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- How relevant is panallergen sensitization in the development of allergies?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2016Review
- Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years.The Journal of allergy and clinical immunology · 2015Article
- Molecular biomarkers for grass pollen immunotherapy.World journal of methodology · 2014Review
- The human IgE repertoire.International archives of allergy and immunology · 2014Review
- Exploring the temporal development of childhood IgE profiles to allergen components.Clinical and translational allergy · 2012Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIgE recognition of panallergens having highly conserved sequence regions, structure, and function and shared by inhalant and food allergen sources is often observed.
methodsWe evaluated the IgE recognition profile of profilins (Bet v 2, Cyn d 12, Hel a 2, Hev b 8, Mer a 1, Ole e 2, Par j 3, Phl p 12, Pho d 2), PR-10 proteins (Aln g 1, Api g 1, Bet v 1.0101, Bet v 1.0401, Cor a 1, Dau c 1 and Mal d 1.0108) and tropomyosins (Ani s 3, Der p 10, Hel as 1, Pen i 1, Pen m 1, Per a 7) using the Immuno-Solid phase Allergen Chip (ISAC) microarray system. The three panallergen groups were well represented among the allergenic molecules immobilized on the ISAC. Moreover, they are distributed in several taxonomical allergenic sources, either close or distant, and have a route of exposure being either inhalation or ingestion.
results3,113 individuals (49.9% female) were selected on the basis of their reactivity to profilins, PR-10 or tropomyosins. 1,521 (48.8%) patients were reactive to profilins (77.6% Mer a 1 IgE(+)), 1,420 (45.6%) to PR-10 (92.5% Bet v 1 IgE(+)) and 632 (20.3%) to tropomyosins (68% Der p 10 IgE(+)). A significant direct relationship between different representative molecules within each group of panallergens was found. 2,688 patients (86.4%) recognized only one out of the three distinct groups of molecules as confirmed also by hierarchical clustering analysis.
conclusionsUnless exposed to most of the allergens in the same or related allergenic sources, a preferential IgE response to distinct panallergens has been recorded. Allergen microarray IgE testing increases our knowledge of the IgE immune response and related epidemiological features within and between homologous molecules better describing the patients' immunological phenotypes.
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