ArticlePloS one2011
Distinguishing characteristics between pandemic 2009-2010 influenza A (H1N1) and other viruses in patients hospitalized with respiratory illness.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Profiling of Intestinal Microbiota in Patients Infected with Respiratory Influenza A and B Viruses.Pathogens (Basel, Switzerland) · 2021Article
- Clinical characteristics and outcomes of influenza A and B virus infection in adult Australian hospitalised patients.BMC infectious diseases · 2020Observational
- Opportunities Revealed for Antimicrobial Stewardship and Clinical Practice with Implementation of a Rapid Respiratory Multiplex Assay.Journal of clinical microbiology · 2019Article
- Epidemiology of viral respiratory infections in Australian working-age adults (20-64 years): 2010-2013.Epidemiology and infection · 2018Article
- Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2016Article
- Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses.PloS one · 2015Article
- Clinical characteristics and outcomes of severe rhinovirus-associated pneumonia identified by bronchoscopic bronchoalveolar lavage in adults: comparison with severe influenza virus-associated pneumonia.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Article
- Article
- Clinical diagnosis of pandemic A(H1N1) 2009 influenza in children with negative rapid influenza diagnostic test by lymphopenia and lower C-reactive protein levels.Influenza and other respiratory viruses · 2014Article
- Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain.Influenza and other respiratory viruses · 2013Article
- Distribution of influenza and other acute respiratory viruses during the first year after the 2009-2010 influenza pandemic in the English- and Dutch-speaking Caribbean countries.Influenza and other respiratory viruses · 2013Article
- Establishing a national influenza sentinel surveillance system in a limited resource setting, experience of Sierra Leone.Health research policy and systems · 2013Article
- Excess mortality associated with the 2009 A(H1N1)v influenza pandemic in Antananarivo, Madagascar.Epidemiology and infection · 2013Article
- High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded autopsy lung tissue sample from the 1918 influenza pandemic.The Journal of pathology · 2013Article
- Rhino/enteroviruses in hospitalized children: a comparison to influenza viruses.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2013Article
- Rhinovirus genetic diversity among immunosuppressed and immunocompetent patients presenting with a severe respiratory infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2013Article
- Article
- Circulation of other respiratory viruses and viral co-infection during the 2009 pandemic influenza.Enfermedades infecciosas y microbiologia clinica · 2012Review
- Simultaneous investigation of influenza and enteric viruses in the stools of adult patients consulting in general practice for acute diarrhea.Virology journal · 2012Article
- Severity of human rhinovirus infection in immunocompromised adults is similar to that of 2009 H1N1 influenza.Journal of clinical microbiology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferences in clinical presentation and outcomes among patients infected with pandemic 2009 influenza A H1N1 (pH1N1) compared to other respiratory viruses have not been fully elucidated. METHODOLOGY/PRINCIPAL
findingsA retrospective study was performed of all hospitalized patients at the peak of the pH1N1 season in whom a single respiratory virus was detected by a molecular assay targeting 18 viruses/subtypes (RVP, Luminex xTAG). Fifty-two percent (615/1192) of patients from October, 2009 to December, 2009 had a single respiratory virus (291 pH1N1; 207 rhinovirus; 45 RSV A/B; 37 parainfluenza; 27 adenovirus; 6 coronavirus; and 2 metapneumovirus). No seasonal influenza A or B was detected. Individuals with pH1N1, compared to other viruses, were more likely to present with fever (92% & 70%), cough (92% & 86%), sore throat (32% & 16%), nausea (31% & 8%), vomiting (39% & 30%), abdominal pain (14% & 7%), and a lower white blood count (8,500/L & 13,600/L, all p-values<0.05). In patients with cough and gastrointestinal complaints, the presence of subjective fever/chills independently raised the likelihood of pH1N1 (OR 10). Fifty-five percent (336/615) of our cohort received antibacterial agents, 63% (385/615) received oseltamivir, and 41% (252/615) received steroids. The mortality rate of our cohort was 1% (7/615) and was higher in individuals with pH1N1 compared to other viruses (2.1% & 0.3%, respectively; p = 0.04). CONCLUSIONS/SIGNIFICANCE: During the peak pandemic 2009-2010 influenza season in Rhode Island, nearly half of patients admitted with influenza-like symptoms had respiratory viruses other than influenza A. A high proportion of patients were treated with antibiotics and pH1N1 infection had higher mortality compared to other respiratory viruses.
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