SynthesisPloS one2011
Knowledge, perceptions and information about hormone therapy (HT) among menopausal women: a systematic review and meta-synthesis.
Synthesis in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Evaluation of Clinical Meaningfulness of Red Clover (Nutrients · 2021Pooled it
- Australian Women's Knowledge of Perimenopause and Menopause.Journal of transcultural nursing : official journal of the Transcultural Nursing Society · 2026Article
- Utilisation of hormone replacement therapy in Arab countries: a systematic review.Frontiers in global women's health · 2026Review
- BRCA mutation carriers' perceptions on postmenopausal hormone therapy: An Italian study.Psycho-oncology · 2021Article
- Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.PloS one · 2021Article
- Beliefs, knowledge and the impact of COVID19 on menopause therapies in Spanish women: COMEM-treatment study.BMC women's health · 2020Article
- EEG Revealed That Fragrances Positively Affect Menopausal Symptoms in Mid-life Women.Experimental neurobiology · 2020Article
- Hormone Replacement Therapy: Lebanese Women's Awareness, Perception, and Acceptance.Obstetrics and gynecology international · 2020Article
- Sexual functioning in 4,418 postmenopausal women participating in UKCTOCS: a qualitative free-text analysis.Menopause (New York, N.Y.) · 2019Article
- Adverse effects of media reports on the treatment of osteoporosis.Journal of endocrinological investigation · 2018Review
- Why women choose compounded bioidentical hormone therapy: lessons from a qualitative study of menopausal decision-making.BMC women's health · 2017Article
- Primary care nurses' experiences of how the mass media influence frontline healthcare in the UK.BMC family practice · 2013Article
- Correlation between the modified Kupperman Index and the Menopause Rating Scale in Chinese women.Patient preference and adherence · 2013Article
- Comparisons of prediction models of quality of life after laparoscopic cholecystectomy: a longitudinal prospective study.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of hormone therapy (HT) by menopausal women has declined since the Women's Health Initiative randomized trial (WHI) in 2002 demonstrated important harms associated with long-term use. However, how this information has influenced women's knowledge and attitudes is uncertain. We aimed to evaluate the attitudes and perceptions towards HT use, as well as specific concerns and information sources on HT since the WHI trial. METHOD/
resultsWe did a systematic review to assess the attitudes and knowledge towards HT in women, and estimate the magnitude of the issue by pooling across the studies. Using meta-synthesis methods, we reviewed qualitative studies and surveys and performed content analysis on the study reports. We pooled quantitative studies using a random-effects meta-analysis. We analyzed 11 qualitative studies (n = 566) and 27 quantitative studies (n = 39251). Positive views on HT included climacteric symptom control, prevention of osteoporosis and a perceived improvement in quality of life. Negative factors reported included concerns about potential harmful effects, particularly cancer risks. Sources of information included health providers, media, and social contact. By applying a meta-synthesis approach we demonstrate that these findings are broadly applicable across large groups of patients.
conclusionsAlthough there are clear hazards associated with long-term HT use, many women view HT favorably for climacteric symptom relief. Media, as a source of information, is often valued as equivalent to health providers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.