ArticlePloS one2011
Cellular scale anisotropic topography guides Schwann cell motility.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Tuning hydrogel properties and Schwann cell behavior through microchannel size control in magnetically templated hydrogels.Biomaterials science · 2026Article
- Sex-based differences in cell migration on aligned topographies.Scientific reports · 2025Article
- Influence of Titanium Surface Residual Stresses on Osteoblastic Response and Bacteria Colonization.Materials (Basel, Switzerland) · 2024Article
- Microfluidic Systems for Neural Cell Studies.Bioengineering (Basel, Switzerland) · 2023Review
- Submicron-Grooved Films Modulate the Directional Alignment and Biological Function of Schwann Cells.Journal of functional biomaterials · 2023Article
- Topographical and Chemical Inductive Cues Synergistically Enhance the Schwann Cell Differentiation of Aligned Dental Pulp Stem Cell Sheets.Journal of tissue engineering and regenerative medicine · 2023Article
- The role of mechanobiology on the Schwann cell response: A tissue engineering perspective.Frontiers in cellular neuroscience · 2022Review
- Microtopographical patterns promote different responses in fibroblasts and Schwann cells: A possible feature for neural implants.Journal of biomedical materials research. Part A · 2021Article
- 3D Printed Neural Regeneration Devices.Advanced functional materials · 2020Article
- Modular approach for resolving and mapping complex neural and other cellular structures and their associated deformation fields in three dimensions.Nature protocols · 2018Article
- Curvotaxis directs cell migration through cell-scale curvature landscapes.Nature communications · 2018Article
- Elasticity patterns induced by phase-separation in polymer blend films.Thin solid films · 2017Article
- Implications of Schwann Cells Biomechanics and Mechanosensitivity for Peripheral Nervous System Physiology and Pathophysiology.Frontiers in molecular neuroscience · 2017Review
- Schwann Cells Migration on Patterned Polydimethylsiloxane Microgrooved Surface.Tissue engineering. Part C, Methods · 2016Article
- Thermally drawn fibers as nerve guidance scaffolds.Biomaterials · 2016Article
- The Impact of Prestretch Induced Surface Anisotropy on Axon Regeneration.Tissue engineering. Part C, Methods · 2016Article
- A Unidirectional Cell Switching Gate by Engineering Grating Length and Bending Angle.PloS one · 2016Article
- Polymer scaffolds with preferential parallel grooves enhance nerve regeneration.Tissue engineering. Part A · 2015Article
- Expression of purinergic receptor P2Y4 in Schwann cell following nerve regeneration.International journal of clinical and experimental medicine · 2015Article
- Three-dimensional traction forces of Schwann cells on compliant substrates.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Directed migration of Schwann cells (SC) is critical for development and repair of the peripheral nervous system. Understanding aspects of motility specific to SC, along with SC response to engineered biomaterials, may inform strategies to enhance nerve regeneration. Rat SC were cultured on laminin-coated microgrooved poly(dimethyl siloxane) platforms that were flat or presented repeating cellular scale anisotropic topographical cues, 30 or 60 µm in width, and observed with timelapse microscopy. SC motion was directed parallel to the long axis of the topography on both the groove floor and the plateau, with accompanying differences in velocity and directional persistence in comparison to SC motion on flat substrates. In addition, feature dimension affected SC morphology, alignment, and directional persistence. Plateaus and groove floors presented distinct cues which promoted differential motility and variable interaction with the topographical features. SC on the plateau surfaces tended to have persistent interactions with the edge topography, while SC on the groove floors tended to have infrequent contact with the corners and walls. Our observations suggest the capacity of SC to be guided without continuous contact with a topographical cue. SC exhibited a range of distinct motile morphologies, characterized by their symmetry and number of extensions. Across all conditions, SC with a single extension traveled significantly faster than cells with more or no extensions. We conclude that SC motility is complex, where persistent motion requires cellular asymmetry, and that anisotropic topography with cellular scale features can direct SC motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.