ArticleSystems and synthetic biology2011
The ten grand challenges of synthetic life.
Article in Systems and synthetic biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Chemical organizations as a conceptual tool: from synthetic biology to interdisciplinary systems and back.Frontiers in bioengineering and biotechnology · 2026Article
- On the Response of Proteinoid Ensembles to Fibonacci Sequences.ACS omega · 2025Article
- Empirical vitalism: observing an organism's formative power within an active and co-constitutive relation between subject and object.History and philosophy of the life sciences · 2025Article
- Artificial cell design: reconstructing biology for life science applications.Emerging topics in life sciences · 2022Review
- Article
- Scientific iconoclasm and active imagination: synthetic cells as techno-scientific mandalas.Life sciences, society and policy · 2018Article
- Self-replication of DNA by its encoded proteins in liposome-based synthetic cells.Nature communications · 2018Article
- Article
- Bacterial cell-free expression technology toSynthetic and systems biotechnology · 2017Review
- Image of Synthetic Biology and Nanotechnology: A Survey among University Students.Frontiers in genetics · 2017Article
- A computational study of dsDNA pairs and vibrational resonance in separating water.Systems and synthetic biology · 2014Article
- Designer microbes for biosynthesis.Current opinion in biotechnology · 2014Review
- Divided we stand: splitting synthetic cells for their proliferation.Systems and synthetic biology · 2014Review
- Systems biology perspectives on minimal and simpler cells.Microbiology and molecular biology reviews : MMBR · 2014Review
- A predictor for predicting Escherichia coli transcriptome and the effects of gene perturbations.BMC bioinformatics · 2014Article
- Hidden hysteresis - population dynamics can obscure gene network dynamics.Journal of biological engineering · 2013Article
- Designing de novo: interdisciplinary debates in synthetic biology.Systems and synthetic biology · 2013Article
- A computational pipeline for identifying kinetic motifs to aid in the design and improvement of synthetic gene circuits.BMC bioinformatics · 2013Article
- What Symbionts Teach us about Modularity.Frontiers in bioengineering and biotechnology · 2013Review
- Are we doing synthetic biology?Systems and synthetic biology · 2012Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
The construction of artificial life is one of the main scientific challenges of the Synthetic Biology era. Advances in DNA synthesis and a better understanding of regulatory processes make the goal of constructing the first artificial cell a realistic possibility. This would be both a fundamental scientific milestone and a starting point of a vast range of applications, from biofuel production to drug design. However, several major issues might hamper the objective of achieving an artificial cell. From the bottom-up to the selection-based strategies, this work encompasses the ten grand challenges synthetic biologists will have to be aware of in order to cope with the task of creating life in the lab.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.