ArticlePLoS pathogens2011
Step-wise loss of bacterial flagellar torsion confers progressive phagocytic evasion.
Article in PLoS pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
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- EprX associates with concurrent shifts in antimicrobial resistance and virulence in clinical bloodstreamFrontiers in cellular and infection microbiology · 2026Article
- Within-host bacterial evolution and the emergence of pathogenicity.Nature microbiology · 2025Review
- Biofilm Formation ofMicroorganisms · 2025Review
- Genomic diversity and evolutionary patterns ofMicrobial genomics · 2025Article
- MotGen: a closed-loop bacterial motility control framework using generative adversarial networks.Bioinformatics (Oxford, England) · 2024Article
- Review
- Assessment of the Glycan-Binding Profile of Pseudomonas aeruginosa PAO1.Microbiology spectrum · 2023Article
- Assessment of the Glycan-Binding Profile ofbioRxiv : the preprint server for biology · 2023Article
- HowInternational journal of molecular sciences · 2023Review
- Mechanism of resistance to phagocytosis and pulmonary persistence in mucoidFrontiers in cellular and infection microbiology · 2023Article
- Adaptation to an amoeba host drives selection of virulence-associated traits in Vibrio cholerae.The ISME journal · 2022Article
- Genome characterization of a uropathogenicFrontiers in cellular and infection microbiology · 2022Article
- Flagella at the Host-Microbe Interface: Key Functions Intersect With Redundant Responses.Frontiers in immunology · 2022Review
- Identification of cell-surface glycans that mediate motility-dependent binding and internalization of Pseudomonas aeruginosa by phagocytes.Molecular immunology · 2021Article
- Host-induced spermidine production in motileeLife · 2020Article
- Elevated exopolysaccharide levels in Pseudomonas aeruginosa flagellar mutants have implications for biofilm growth and chronic infections.PLoS genetics · 2020Article
- Distinct Contributions of CD18 Integrins for Binding and Phagocytic Internalization of Pseudomonas aeruginosa.Infection and immunity · 2020Article
- Motility-Independent Formation of Antibiotic-Tolerant Pseudomonas aeruginosa Aggregates.Applied and environmental microbiology · 2019Article
- Motility and biofilm formation of the emerging gastrointestinal pathogen Campylobacter concisus differs under microaerophilic and anaerobic environments.Gut microbes · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Phagocytosis of bacteria by innate immune cells is a primary method of bacterial clearance during infection. However, the mechanisms by which the host cell recognizes bacteria and consequentially initiates phagocytosis are largely unclear. Previous studies of the bacterium Pseudomonas aeruginosa have indicated that bacterial flagella and flagellar motility play an important role in colonization of the host and, importantly, that loss of flagellar motility enables phagocytic evasion. Here we use molecular, cellular, and genetic methods to provide the first formal evidence that phagocytic cells recognize bacterial motility rather than flagella and initiate phagocytosis in response to this motility. We demonstrate that deletion of genes coding for the flagellar stator complex, which results in non-swimming bacteria that retain an initial flagellar structure, confers resistance to phagocytic binding and ingestion in several species of the gamma proteobacterial group of Gram-negative bacteria, indicative of a shared strategy for phagocytic evasion. Furthermore, we show for the first time that susceptibility to phagocytosis in swimming bacteria is proportional to mot gene function and, consequently, flagellar rotation since complementary genetically- and biochemically-modulated incremental decreases in flagellar motility result in corresponding and proportional phagocytic evasion. These findings identify that phagocytic cells respond to flagellar movement, which represents a novel mechanism for non-opsonized phagocytic recognition of pathogenic bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.