ArticleFrontiers in microbiology2011
Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents.
Article in Frontiers in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review).Obesity surgery · 2023Pooled it
- Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery-A Systematic Review of Their Interrelation.Nutrients · 2020Pooled it
- The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review.International journal of obesity (2005) · 2015Pooled it
- Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota.Genome medicine · 2016Trial
- Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption.BioMed research international · 2015Trial
- Integrative multi-omics analysis unravels the metabolic landscape and reveals serum biomarkers for early diagnosis of hyperuricemia.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review.Frontiers in nutrition · 2024Review
- Urinary Metabolomic Changes Accompanying Albuminuria Remission following Gastric Bypass Surgery for Type 2 Diabetic Kidney Disease.Metabolites · 2022Article
- Mechanisms of Weight Loss After Obesity Surgery.Endocrine reviews · 2022Review
- Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity.Communications medicine · 2022Article
- Ileal microbial shifts after Roux-en-Y gastric bypass orchestrate changes in glucose metabolism through modulation of bile acids and L-cell adaptation.Scientific reports · 2021Article
- Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype.Microbiome · 2021Article
- The association between obesity and weight loss after bariatric surgery on the vaginal microbiota.Microbiome · 2021Article
- Gut Microbiota in Patients with Morbid Obesity Before and After Bariatric Surgery: a Ten-Year Review Study (2009-2019).Obesity surgery · 2021Review
- Bariatric Surgery Is Associated with a Recent Temporal Increase in Colorectal Cancer Resections, Most Pronounced in Adults Below 50 Years of Age.Obesity surgery · 2020Article
- Two Bariatric Surgical Procedures Differentially Alter the Intestinal Microbiota in Obesity Patients.Obesity surgery · 2020Article
- The Long-term Impact of Roux-en-Y Gastric Bypass on Colorectal Polyp Formation and Relation to Weight Loss Outcomes.Obesity surgery · 2020Article
- HastaLaVista, a web-based user interface for NMR-based untargeted metabolic profiling analysis in biomedical sciences: towards a new publication standard.Journal of cheminformatics · 2019Article
- Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut.JPEN. Journal of parenteral and enteral nutrition · 2018Review
- Colorectal carcinogenesis: an archetype of gut microbiota-host interaction.Ecancermedicalscience · 2018Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Bariatric surgery, also known as metabolic surgery, is an effective treatment for morbid obesity, which also offers pronounced metabolic effects including the resolution of type 2 diabetes and a decrease in cardiovascular disease and long-term cancer risk. However, the mechanisms of surgical weight loss and the long-term consequences of bariatric surgery remain unclear. Bariatric surgery has been demonstrated to alter the composition of both the microbiome and the metabolic phenotype. We observed a marked shift toward Gammaproteobacteria, particularly Enterobacter hormaechei, following Roux-en-Y gastric bypass (RYGB) surgery in a rat model compared with sham-operated controls. Fecal water from RYGB surgery rats was highly cytotoxic to rodent cells (mouse lymphoma cell line). In contrast, fecal water from sham-operated animals showed no/very low cytotoxicity. This shift in the gross structure of the microbiome correlated with greatly increased cytotoxicity. Urinary phenylacetylglycine and indoxyl sulfate and fecal gamma-aminobutyric acid, putrescine, tyramine, and uracil were found to be inversely correlated with cell survival rate. This profound co-dependent response of mammalian and microbial metabolism to RYGB surgery and the impact on the cytotoxicity of the gut luminal environment suggests that RYGB exerts local and global metabolic effects which may have an influence on long-term cancer risk and cytotoxic load.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.