ArticlePsychosomatic medicine2011
Testosterone in newly diagnosed, antipsychotic-naive men with nonaffective psychosis: a test of the accelerated aging hypothesis.
Article in Psychosomatic medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Impaired Glucose Metabolism in Young Patients with First-episode Schizophrenia Aged from 16 to 35 Years.Current neuropharmacology · 2026Article
- The Pathobiological Underpinnings of Psychosis: From the Stress-Related Hypothesis to a Multisystemic Approach.NeuroSci · 2025Review
- Epiphenomena in psychosis: how perinatal stressful events shape long-term outcomes.Molecular psychiatry · 2025Review
- Gonadal hormone abnormalities in young patients with first-episode schizophrenia.The international journal of neuropsychopharmacology · 2024Article
- Clozapine suppresses NADPH oxidase activation, counteracts cytosolic HRedox biology · 2023Article
- Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review).Experimental and therapeutic medicine · 2020Review
- Biological Aspects of Aggression and Violence in Schizophrenia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions.Schizophrenia bulletin · 2018Review
- The Complex Relationship between Antipsychotic-Induced Weight Gain and Therapeutic Benefits: A Systematic Review and Implications for Treatment.Frontiers in neuroscience · 2017Review
- Growing up or growing old? Cellular aging linked with testosterone reactivity to stress in youth.The American journal of the medical sciences · 2014Article
- Accelerated aging in schizophrenia patients: the potential role of oxidative stress.Aging and disease · 2014Review
- Schizophrenia: a systemic disorder.Clinical schizophrenia & related psychoses · 2014Review
- Ageing: Live faster, die younger.Nature · 2014Article
- The development of psychotic disorders in adolescence: a potential role for hormones.Hormones and behavior · 2013Review
- Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression.Biological psychiatry · 2013Article
- Inverse association between cancer risks and age in schizophrenic patients: a 12-year nationwide cohort study.Cancer science · 2013Article
- The role of estrogen in the treatment of men with schizophrenia.International journal of endocrinology and metabolism · 2013Review
- Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia.PloS one · 2013Article
- Investigation on psychological symptoms improves ANDROTEST accuracy in predicting hypogonadism in subjects with sexual dysfunction.International journal of impotence research · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveSchizophrenia has been associated with age-related abnormalities, including abnormal glucose tolerance, increased pulse pressure, increased inflammation, abnormal stem cell signaling, and shorter telomere length. These metabolic abnormalities and other findings suggest that schizophrenia and related disorders might be associated with accelerated aging. Testosterone activity has a progressive decline with increasing age.
methodsWe tested the hypothesis that circulating biologically active testosterone is lower in newly diagnosed, antipsychotic-naive male patients with nonaffective psychosis than in matched control subjects.
resultsPatients (n = 33) were matched to control subjects (n = 33) for age, sex, body mass index, socioeconomic status of the family of origin, and smoking. The free androgen index, a measure of biologically active testosterone, was significantly lower in the psychosis group (mean [standard deviation] = 57.7% [26.1]) than in control subjects (71.6% [27.0], p = .04), with an effect size of 0.53. Multivariate analysis also supported the findings. In the psychosis group, free androgen index had a significant negative correlation with the conceptual disorganization item (r = -0.35, p = .049) but not with reality distortion (r = -0.21, p = .24), negative symptoms (r = 0.004, p = .98), or depression (r = -0.014, p = .94).
conclusionsLower testosterone level is consistent with accelerated aging in nonaffective psychosis, but further testing of this hypothesis is needed.
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Registered trials
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